Evidence map›Paper›PMID 40817325›Full record

ArticleBMC research notes2025

Investigating microbial population structure and function in the chicken caeca and large intestine over time using metagenomics.

Banaz Star-Shirko, Gladys Maria Pangga, Aaron McKenna, Nicolae Corcionivoschi, Anne Richmond, Umer Zeeshan Ijaz, Ozan Gundogdu

Abstract read
In one paragraph

Article in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Banaz Star-ShirkoFaculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.
Gladys Maria PanggaFaculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.
Aaron McKennaPilgrim's Europe Ltd, Craigavon, UK.
Nicolae CorcionivoschiFood Microbiology, Agri-Food and Biosciences Institute, Newforge Lane, Belfast, UK.
Anne RichmondPilgrim's Europe Ltd, Craigavon, UK.
Umer Zeeshan IjazJames Watt School of Engineering, University of Glasgow, Glasgow, UK. Umer.Ijaz@glasgow.ac.uk.ORCID http://orcid.org/0000-0001-5780-8551
Ozan GundogduFaculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK. Ozan.Gundogdu@lshtm.ac.uk.ORCID http://orcid.org/0000-0002-3550-0545

Funding

Engineering and Physical Sciences Research Council EP/V030515/1
6 · The paper itself

Abstract

objectivesAlthough taxonomic variations in chicken gut microbiota have been previously documented, their functional capacity remain poorly understood. To gain a better understanding, we incorporated whole genome shotgun metagenomics to analyse microbial communities of two different organs: the caeca and the large intestine.

resultsUsing 24 samples obtained from the caeca and the large intestine of commercial chickens, we assembled Metagenome-Assembled Genomes (MAGs) and characterise their functional profiles. Afterwards, using 8 samples, we integrated this sequencing data with chicken performance metadata body weight (BW), weight gain, feed intake (FI), feed conversion ratio (FCR) and age. MAGs belonging to specific families were found to be positively associated with changes in performance parameters. Functional analyses suggest changes in nutrient geochemical cycles including hydrogen generation within the carbon-cycle. Furthermore, 108 CAZymes were identified for MAGs belonging to two major families - glycoside hydrolase (GH) and polysaccharide lyase (PL), which are important for breakdown of dietary carbohydrates and fibres. A total of 13 polysaccharide lyases were identified functioning on day 20 with enzymes were specific to organs. Overall, our results provide a deeper understanding of microbial-mediated metabolism concerning key performance parameters in chicken production.

Indexed as

CecumChickensGastrointestinal MicrobiomeIntestine, LargeMetagenomicsAnimalsMetagenomeChicken gut microbiomeFunctional profileGastroenteritisMetagenomicsShotgun sequencing

Identifiers

PMID40817325
PMCPMC12357378

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.