Evidence map›Paper›PMID 40817291›Full record

ArticlePediatric research2026

Impact of resuscitation with 100% oxygen during physiological-based cord clamping or immediate cord clamping on lung inflammation and injury.

Zoe Poulos, Emma Vandenberg, Zoe Johnson, Valerie A Zahra, Hui Lu, Alison Thiel, Stuart B Hooper, Ebony R Cannata, Shiraz Badurdeen, Robert Galinsky and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Zoe Poulos *The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia.
Emma Vandenberg *The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia.
Zoe JohnsonThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia.
Valerie A ZahraThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia.
Hui LuThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia.
Alison ThielThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia.
Stuart B HooperThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia.
Ebony R CannataThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia.
Shiraz BadurdeenDepartment of Paediatrics, Mercy Hospital for Women, Heidelberg, VIC, Australia.
Robert GalinskyThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia.
Nhi TranThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia.
Georg M SchmölzerDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Arjan Te PasDivision of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands.
Andrew W GillCentre for Neonatal Research and Education, The University of Western Australia, Subiaco, WA, Australia.
Martin KluckowDepartment of Neonatology, Royal North Shore Hospital & University of Sydney, Sydney, NSW, Australia.
Calum T RobertsThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia.
Graeme R PolglaseThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia. graeme.polglase@monash.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe examined whether physiological based cord clamping (PBCC) reduces oxygen-induced lung inflammation compared to immediate cord clamping (ICC) in preterm lambs ventilated with 100% oxygen for 10 min after birth.

methodsInstrumented, steroid exposed preterm lambs (125 ± 1 days' gestation) were randomized to receive 10 min of resuscitation with 100% oxygen before umbilical cord clamping or 30 s after ICC. After 10 min, oxygen was titrated to target SpO

resultsPBCC prevented the transient fall in SpO

conclusionPBCC prevents initial hypoxia and subsequent hyperoxia from 100% oxygen ventilation, but it does not reduce lung oxidative stress, inflammation, or injury, nor the risk or severity of lung damage during high-oxygen resuscitation. IMPACT: The appropriate oxygen level to use during the initial resuscitation of preterm infants during delayed cord clamping/physiological based cord clamping is not known. We found that providing prolonged high oxygen during physiological based cord clamping to preterm lambs does not protect the preterm lung from inflammation, injury or oxidative stress compared to immediate cord clamping. The use of prolonged high oxygen during the initial resuscitation of preterm newborns should be avoided irrespective of what cord clamping strategy is being used.

Indexed as

Lung InjuryOxygenPneumoniaResuscitationUmbilical CordUmbilical Cord ClampingAnimalsAnimals, NewbornConstrictionDisease Models, AnimalFemaleHyperoxiaInflammationLungOxidative StressPregnancyOxygen

Identifiers

PMID40817291
PMCPMC13485692

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.