ReviewNature reviews. Neurology2025
Targeting sodium channels - challenges for acute pain and the leap to chronic pain.
Review in Nature reviews. Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- First-in-Human Phase I Trial of HRS-2129, a Selective Nav1.8 Inhibitor: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics in Healthy Subjects.Drug design, development and therapy · 2026Trial
- Classic Psychedelics for Treating Chronic Pain: Mechanism and Clinical Translation.Molecules (Basel, Switzerland) · 2026Review
- Functional characterization of human iPSC-derived sensory neuron processes in microfluidic cultures.Stem cells translational medicine · 2026Article
- Combinatorial logic of Nav channels in nociceptor excitability: Different degrees of synergy define distinct neuronal groups.bioRxiv : the preprint server for biology · 2026Article
- The Excelsatoxin A-Receptor TMEM233 Modulates Nav1.8.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- From ion channel biology to clinical practice: suzetrigine as a precision analgesic.Frontiers in medicine · 2026Review
- The cell-type-specific genetic architecture of chronic pain in brain and dorsal root ganglia.The Journal of clinical investigation · 2025Article
- Etiological basis for chronic pain genetic variation in brain and dorsal root ganglia cell types.medRxiv : the preprint server for health sciences · 2025Article
- Biophysical dissection of nociceptor hyperexcitability caused by a Nav1.8 gain-of-function mutation linked to severe pain.Neurobiology of pain (Cambridge, Mass.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Treatment of pain is a challenge for almost all clinicians, ranging from general practitioners to subspecialists such as pain medicine physicians, surgeons, neurologists and physiatrists. Over the past few years, clinical studies in people with acute postoperative pain have demonstrated that pain in humans can be reduced by inhibiting Nav1.8, a sodium channel that is essential for repetitive firing of peripheral pain-signalling neurons and has no essential function in the CNS. This discovery is an important step forward, but pain reduction in these studies was partial, not complete. Moreover, success via this approach thus far has been limited to people with acute pain, and translation to chronic pain must still be confronted. In this Perspective, we discuss the key questions of whether more effective Nav1.8 blockers can be built and whether neural mechanisms impose a ceiling on the pain relief that can be achieved by Nav1.8 inhibition. We then explore the challenge of developing therapeutics for chronic pain and ask whether compensatory changes or development of pain generators within the CNS might limit pain relief. Finally, we discuss the clinical complexity of pain and its implications for therapy and pose questions and suggest opportunities for the future.
Indexed as
Identifiers
40817289What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.