Evidence map›Paper›PMID 40817172›Full record

ArticleCognitive, affective & behavioral neuroscience2025

Role of left lateral prefrontal cortex in positive emotion regulation: Insights from dyslexia.

Eleanor R Palser, Nathaniel A Morris, Christina R Veziris, Sarah R Holley, Amie Wallman-Jones, Ashlin R K Roy, Abigail E Licata, Mieke Voges, Christa Watson Pereira, Maria Luisa Mandelli and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cognitive, affective & behavioral neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Eleanor R PalserDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-2760-4184
Nathaniel A MorrisDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Christina R VezirisDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Sarah R HolleyDepartment of Psychology, Palo Alto University, Palo Alto, CA, USA.
Amie Wallman-JonesDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Ashlin R K RoyDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Abigail E LicataDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Mieke VogesDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Christa Watson PereiraDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Maria Luisa MandelliDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Maria Luisa Gorno-TempiniDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.
Virginia E SturmDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA. virginia.sturm@ucsf.edu.

Funding

Progressive Aphasia Cognition Anatomy and ProgressionR01NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI · 2004 to 2026
$11.0M
Training program in the neurology of language and neurodegenerative aphasiasK24DC015544 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2016 to 2025
$1.9M
NIDCD NIH HHS K24 DC015544NIDCD NIH HHS K24DC015544NINDS NIH HHS R01 NS050915NINDS NIH HHS R01NS050915
6 · The paper itself

Abstract

Emotion regulation emerges during childhood and engages prefrontal brain systems. While most developmental studies focus on the neural underpinnings of negative emotion regulation, less is known about the neuroanatomical correlates of positive emotion regulation. In adults, prefrontal areas in the left hemisphere are critical for positive emotion regulation, but whether this association is present in children is unknown. We investigated whether smaller gray matter volume in left prefrontal regions related to worse positive emotion regulation in children with and without dyslexia. Because dyslexia is a neurodevelopmental disorder of reading in which there may be greater variability in left prefrontal structures, it offers a unique window into the neural basis of positive emotion regulation. Sixty-nine children (ages 7-13) were asked to hide their feelings while watching film clips that elicited either amusement or disgust, and evaluate their emotion regulation performance. Parents reported on children's everyday emotion regulation. Across the sample, children with smaller volumes in left prefrontal regions (i.e., lateral orbitofrontal cortex and dorsolateral prefrontal cortex) had greater facial behavior (i.e., suggesting worse positive emotion regulation) yet more positive self-reported emotion regulation success during the amusement trial (i.e., suggesting more favorable self-evaluation). These regions did not relate to disgust regulation, however. Children with more positive views of their emotion regulation success also had better everyday parent-reported emotion regulation. Results suggest that positive emotion regulation in childhood relies on left prefrontal regions and a more optimistic view of one's emotion regulation abilities, regardless of one's actual emotional behavior, may confer real-world advantages.

Indexed as

DyslexiaEmotional RegulationEmotionsPrefrontal CortexAdolescentChildFemaleFunctional LateralityGray MatterHumansMagnetic Resonance ImagingMaleAdolescenceApproachLateralityLearning differencesPositivitySuppression

Identifiers

PMID40817172
PMCPMC12615568

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.