Evidence map›Paper›PMID 40817118›Full record

ArticleNature communications2025

Matrix regulation: a plug-and-tune method for combinatorial regulation in Saccharomyces cerevisiae.

Xiaolong Teng, Zibai Wang, Yueping Zhang, Binhao Wang, Guiping Gong, Jinmiao Hu, Yifan Zhu, Baoyi Peng, Junyang Wang, James Chen and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiaolong Teng *College of Life Science and Technology, State Key Laboratory of Green Biomanufacturing, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, China.
Zibai Wang *College of Life Science and Technology, State Key Laboratory of Green Biomanufacturing, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, China.
Yueping Zhang *College of Veterinary Medicine, China Agricultural University, Beijing, China.
Binhao WangCollege of Life Science and Technology, State Key Laboratory of Green Biomanufacturing, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, China.
Guiping GongCollege of Life Science and Technology, State Key Laboratory of Green Biomanufacturing, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, China.
Jinmiao HuCollege of Life Science and Technology, State Key Laboratory of Green Biomanufacturing, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, China.
Yifan ZhuCollege of Life Science and Technology, State Key Laboratory of Green Biomanufacturing, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, China.
Baoyi PengCollege of Life Science and Technology, State Key Laboratory of Green Biomanufacturing, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, China.
Junyang WangCollege of Life Science and Technology, State Key Laboratory of Green Biomanufacturing, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, China.
James ChenCollege of Life Science and Technology, State Key Laboratory of Green Biomanufacturing, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, China.
Shuobo ShiCollege of Life Science and Technology, State Key Laboratory of Green Biomanufacturing, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, China.ORCID http://orcid.org/0000-0002-0261-3105
Jens NielsenCollege of Life Science and Technology, State Key Laboratory of Green Biomanufacturing, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, China.ORCID http://orcid.org/0000-0002-9955-6003
Zihe LiuCollege of Life Science and Technology, State Key Laboratory of Green Biomanufacturing, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, China. zihe@mail.buct.edu.cn.ORCID http://orcid.org/0000-0002-4199-1627

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22078012National Natural Science Foundation of China (National Science Foundation of China) 22211530047Novo Nordisk Fonden (Novo Nordisk Foundation) NNF10CC1016517
6 · The paper itself

Abstract

Transcriptional fine-tuning of long pathways is complex, even in the extensively applied cell factory Saccharomyces cerevisiae. Here, we present Matrix Regulation (MR), a CRISPR-mediated pathway fine-tuning method enabling the construction of 6

Indexed as

CRISPR-Cas SystemsGene Expression Regulation, FungalSaccharomyces cerevisiaeHemeMevalonic AcidRNA, Guide, CRISPR-Cas SystemsRNA, TransferSaccharomyces cerevisiae ProteinsHemeMevalonic AcidRNA, Guide, CRISPR-Cas SystemsRNA, TransferSaccharomyces cerevisiae Proteins

Identifiers

PMID40817118
PMCPMC12356856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.