ArticleParasites & vectors2025
Impact of levels of parasitemia and antibodies, acute-phase proteins, as well as stays abroad on hematological and biochemical parameters in 342 dogs with acute Babesia canis infection.
Article in Parasites & vectors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Comparison of Westergren and Automated Erythrocyte Sedimentation Rate Measurements in Dogs and Cats.Animals : an open access journal from MDPI · 2026Article
- Treatment failure in a dog with acute Babesia canis infection using lower-range therapeutic doses of imidocarb dipropionate.Parasitology research · 2026Article
- Clinicopathological abnormalities and outcome of acuteCurrent research in parasitology & vector-borne diseases · 2026Article
- Retrospective analysis of anamnesis, clinical signs, therapy, and outcome in 342 dogs with acuteCurrent research in parasitology & vector-borne diseases · 2026Article
- Apolipoprotein A-1 does not appear to be a suitable acute-phase reaction marker in canine babesiosis and hemoplasmosis.Current research in parasitology & vector-borne diseases · 2025Article
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7 authors.
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Abstract
backgroundBabesia canis infections are of rising importance in Germany. This retrospective study aimed to correlate hematological and biochemical parameters with acute-phase proteins, levels of parasitemia and antibodies, as well as stays abroad in dogs with acute B. canis infection.
methodsDogs in Germany tested PCR-positive for B. canis and negative for Anaplasma phagocytophilum from January 2018 to December 2024 were included if data on hematocrit, leukocytes, and platelets were available. Hematological scoring (HES) was performed by addition of points for mild (+ 1), moderate (+ 2), and marked (+ 3) anemia, thrombocytopenia, and leukopenia, as well as for the presence of pancytopenia (+ 3) and leukocytosis (+ 1). Results of biochemical and CRP analysis, Babesia antibody determination, and pathogen quantification were included, if available. P ≤ 0.05 in Spearman's rank correlation was considered statistically significant.
results342 dogs were included. History of stays abroad was known for 191/342 dogs (55.8%; no stays abroad 113/191 (59.2%), imported 55/191 (28.8%), travel 23/191 (12.0%)). The most common clinicopathologic findings were increased CRP (87.4%), thrombocytopenia (85.1%), anemia (78.7%), hyperbilirubinemia (74.2%), decreased iron levels (51.1%), and leukopenia (49.7%). Dogs without stays abroad showed significantly higher HES (n = 113, median: 6), CRP (n = 60, median: 116.2 mg/l), and levels of parasitemia (n = 92, median: 2916 × 10
conclusionsAbout 60% of dogs with acute B. canis infection had no history of stays abroad, thus representing autochthonous infections. Most dogs without stays abroad were immunologically naive, in contrast to most imported dogs showing positive and high antibody levels. Dogs with high antibody levels showed less severe clinicopathological alterations and lower levels of parasitemia in the peripheral blood, explained by protective antibody activity.
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