Evidence map›Paper›PMID 40817085›Full record

ArticleBMC public health2025

Effects of oral zinc supplementation in the prevention of community-acquired pneumonia in colombian children: an economic evaluation : Short running title: Cost-effectiveness analysis oral zinc supplementation.

Diana Guerrero Patiño, Mery Ann Rojano Canchila, Jefferson Antonio Buendía

Abstract read
In one paragraph

Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Diana Guerrero PatiñoResearch group in Pharmacology and Toxicology, Department of Pharmacology and Toxicology, Faculty of Medicine, University of Antioquia, Medellín, Colombia.
Mery Ann Rojano CanchilaResearch group in Pharmacology and Toxicology, Department of Pharmacology and Toxicology, Faculty of Medicine, University of Antioquia, Medellín, Colombia.
Jefferson Antonio BuendíaResearch group in Pharmacology and Toxicology, Department of Pharmacology and Toxicology, Faculty of Medicine, University of Antioquia, Medellín, Colombia. jefferson.buendia@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOral zinc supplementation is a well-known intervention, widely used to prevent infectious diseases. However, it is also necessary to demonstrate that it achieves the maximum benefit at the lowest possible cost in pneumonia in children, particularly in low- and middle-income countries. This economic evaluation aims to estimate the cost-utility and cost-effectiveness of zinc supplementation for the prevention of community-acquired pneumonia in children aged 1 to 6 years in Colombia.  MATERIALS AND

methodsUsing the decision tree analysis, we estimated the expected benefits and costs of zinc supplementation versus no supplementation based on data on effectiveness and cost previously published in Colombia. The perspective of the present economic evaluation is the perspective of society with a time horizon of 1 year.

resultsThe net monetary benefit (NMB) with oral zinc supplementation was US$ 5,063.3 (95% UI: 5,061–5,065), compared to US$ 5,062.6 (95% UI: 5,060–5,064) without supplementation. The estimated cost effectiveness ratio was U$ 4 873 per QALY and U$ 10 324 per year lived gained. In the probabilistic sensitivity analysis, oral zinc supplementation was the most cost-effective therapy in the 53.4% of replications at willingness-to-pay (WTP) of U$ 5180 values.

conclusionIn conclusion, oral zinc supplementation in children aged 1 to 6 years in Colombia appears to be a potentially cost-effective strategy for the prevention of community-acquired pneumonia compared to non-supplementation. These findings should be interpreted with caution given the small absolute difference in benefits and the marginal incremental net monetary benefit observed. This result becomes an input for the construction of public health policies aimed at reducing the burden of disease generated by respiratory infections in Colombia, as well as serving as an example and motivation to assess the cost and utility of these strategies in other developing and developed countries.

Indexed as

Community-Acquired PneumoniaDietary SupplementsZincAdministration, OralChildChild, PreschoolColombiaCommunity-Acquired InfectionsCost-Benefit AnalysisCost-Effectiveness AnalysisDecision TreesFemaleHumansInfantMaleZinc

Identifiers

PMID40817085
PMCPMC12355844

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.