SynthesisBMC infectious diseases2025
The prevalence of Leishmania RNA virus in cutaneous leishmaniasis: a meta-analysis and systematic review.
Synthesis in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- From dogma to data: charting a path forward for clinico-immunological research in Ethiopian cutaneous leishmaniasis.Infectious diseases of poverty · 2026Review
- Rodent-Borne Parasites and Human Disease: A Growing Public Health Concern.Animals : an open access journal from MDPI · 2025Review
- Editorial: Drug discovery for leishmaniasis and chagas disease: compound design and therapeutic strategies.Frontiers in pharmacology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhile numerous studies have investigated the role and presence of RNA viruses within Leishmania parasites, the existing literature presents a fragmented view of Leishmania RNA virus (LRV) prevalence in parasites associated with cutaneous leishmaniasis (CL). Therefore, the present study aimed to elucidate the prevalence of LRV in parasites obtained from patients with CL.
methodsTo achieve this aim, we conducted a systematic literature search across international databases, specifically Web of Science, PubMed, Embase, and Scopus. We extracted relevant studies reporting the prevalence of LRV in parasites obtained from patients with CL, utilizing predefined keywords and covering the period from December 1988 to August 2024. The extracted data underwent meta-analysis using a random-effects model, with statistical analyses performed in STATA version 14.
resultsOur search yielded 44 studies that fulfilled the eligibility criteria, representing a total sample size of 2,276 participants. LRV detection was performed on biopsied lesion fragments and cultured isolates derived from these lesions. Among the 2,276 CL patients, 647 tested positive for LRV. We observed regional variations in LRV prevalence, with 45.16% in the New World (NW) and 30.00% in the Old World (OW). The majority of included studies examined Leishmania (Viannia) guyanensis, L. (V.) braziliensis, L. (Leishmania) major, and Leishmania (L.) tropica. LRV prevalence was 32.26% in lesion biopsies and 30.96% in cultured isolates. Notably, LRV exhibited a high prevalence in Leishmania species obtained from mucocutaneous leishmaniasis (MCL), suggesting a strong association between LRV1 and this clinical manifestation in the NW.
conclusionThis study demonstrated a substantial prevalence of LRV in CL. LRV was identified in both lesion biopsies and cultured isolates, revealing significant regional variations with higher prevalence in the NW compared to the OW. Furthermore, a strong association was observed between LRV1 and MCL in the NW.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.