Evidence map›Paper›PMID 40817027›Full record

ArticleHPB : the official journal of the International Hepato Pancreato Biliary Association2025

Enhancing management of pancreatic cancer: impact of a same day multidisciplinary clinic on access to guideline-directed care.

Matthew I Ebia, Anser A Abbas, Abrahm Levi, John Davelaar, Elissa Rosenberg, Katelyn M Atkins, Mitchell Kamrava, Simon Lo, Srinivas Gaddam, Alexandra Gangi and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HPB : the official journal of the International Hepato Pancreato Biliary Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Matthew I EbiaCedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, USA.
Anser A AbbasCedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, USA.
Abrahm LeviCedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, USA.
John DavelaarCedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, USA.
Elissa RosenbergCedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, USA.
Katelyn M AtkinsCedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, USA.
Mitchell KamravaCedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, USA.
Simon LoCedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, USA.
Srinivas GaddamCedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, USA.
Alexandra GangiCedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, USA.
Kambiz KosariCedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, USA.
Arpit AroraCedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, USA.
Nanor HaladjianCedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, USA.
Meghan LaszloCedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, USA.
Steven OppenheimCedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, USA.
Karen L ReckampCedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, USA.
Nicholas NissenCedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, USA.
Brent K LarsonCedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, USA.
Ashley WachsmanCedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, USA.
Jun GongCedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, USA.
Cristina FerroneCedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, USA.
Andrew E HendifarCedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, USA.
Arsen OsipovCedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, USA. Electronic address: arsen.osipov@cshs.org.

Funding

Targeting the Stroma for Pancreatic Cancer TreatmentK08CA259456 · NCI · CEDARS-SINAI MEDICAL CENTER · PI OSIPOV, ARSEN · 2021 to 2025
$1.2M
NCI NIH HHS K08 CA259456NCI NIH HHS L30 CA284423
6 · The paper itself

Abstract

backgroundPancreatic cancer (PC) requires a multimodal treatment approach. We evaluated the impact of our same-day pancreatic multidisciplinary clinic (PMDC) on genetic testing, ancillary service access, treatment timelines, clinical trial enrollment, and survival.

methodsWe retrospectively compared guideline directed care, clinical metrics and outcomes in patients managed through our PMDC (n = 87; Oct 2021-June 2023) versus an age- and resectability-matched cohort from our internal registry who received standard sequential care non-PMDC (n = 87; Jan-Dec 2020).

resultsPMDC patients were significantly more likely to undergo somatic (OR 3.69, p < 0.001) and germline testing (OR 15.41, p < 0.001), receive upfront access palliative care (OR 7.86, p < 0.001) and social services (OR 4.48, p = 0.028), initiate treatment sooner (14.3 vs. 30.9 days, p = 0.002), and enroll in clinical trials (OR 2.30, p = 0.042). Among newly diagnosed metastatic PC patients, PMDC care was independently associated with improved survival (487 vs. 267 days, p = 0.021).

conclusionA same-day PMDC significantly improves access to guideline-recommended care and prolongs survival in patients with metastatic pancreatic cancer.

Indexed as

Health Services AccessibilityPancreatic NeoplasmsPatient Care TeamAgedFemaleGenetic TestingGuideline AdherenceHumansMaleMiddle AgedPalliative CarePractice Guidelines as TopicRetrospective Studies

Identifiers

PMID40817027
PMCPMC12456971

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.