Evidence map›Paper›PMID 40817009›Full record

ArticleThe journal of prevention of Alzheimer's disease2025

A novel early imaging biomarker for glymphatic function: Cerebral cortical arterial pulsatility index from 2-Minute phase-contrast MRI.

Sung-Hye You, Byungjun Kim, Moonjung Hwang, Kyung-Sook Yang, Hye-Won Park, InSeong Kim, SuGil Kim, Kyung Min Kim, Bo Kyu Kim, Jae Ho Shin

Abstract read
In one paragraph

Article in The journal of prevention of Alzheimer's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sung-Hye YouDepartment of Radiology, Anam Hospital, Korea University College of Medicine, 73, Goryeodae-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
Byungjun KimDepartment of Radiology, Anam Hospital, Korea University College of Medicine, 73, Goryeodae-ro, Seongbuk-gu, Seoul 02841, Republic of Korea. Electronic address: bj1492.kim@gmail.com.
Moonjung HwangDepartment of Radiology, Anam Hospital, Korea University College of Medicine, 73, Goryeodae-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
Kyung-Sook YangDepartment of Biostatistics, Korea University College of Medicine, Republic of Korea.
Hye-Won ParkDepartment of Radiology, Anam Hospital, Korea University College of Medicine, 73, Goryeodae-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
InSeong KimSiemens Healthineers, Republic of Korea.
SuGil KimSiemens Healthineers, Republic of Korea.
Kyung Min KimDepartment of Radiology, Anam Hospital, Korea University College of Medicine, 73, Goryeodae-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
Bo Kyu KimDepartment of Radiology, Anam Hospital, Korea University College of Medicine, 73, Goryeodae-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
Jae Ho ShinDepartment of Radiology, Anam Hospital, Korea University College of Medicine, 73, Goryeodae-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundArterial pulsatility is one of the driving forces of glymphatic flow.

objectivesTo evaluate the feasibility of the pulsatility index (PI) of cortical arteries in the centrum semiovale (PI

designRetrospective cross-sectional study.

settingSingle tertiary academic center equipped with both 3.0 T MRI systems.

participantsA total of 160 individuals were enrolled: 50 healthy volunteers, 46 cognitively normal controls, and 64 AD patients who underwent diffusion tensor imaging (DTI) and 2D phase-contrast MRI. MEASUREMENTS: Diffusion Tensor Imaging Analysis along the Perivascular Space (DTI-ALPS) index and PI

resultsPI

conclusionPI

Indexed as

Alzheimer DiseaseCerebral ArteriesGlymphatic SystemMagnetic Resonance ImagingPulsatile FlowAgedBiomarkersCross-Sectional StudiesDiffusion Tensor ImagingFemaleHumansMaleMiddle AgedRetrospective StudiesBiomarkers2D Phase-contrast MRIAlzheimer’s diseaseGlymphaticsPulsatility index

Identifiers

PMID40817009
PMCPMC12501337

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.