Evidence map›Paper›PMID 40816923›Full record

ArticleAcademic radiology2026

Using NIRS-Based Spectroscopy for the Comparison of Cerebral Net-Water Uptake and Microcirculation in Posttraumatic Penumbra in Severe Traumatic Brain Injury Patients.

Alex O Trofimov, Kseniia A Trofimova, Oxana V Semyachkina-Glushkovskaya, Edwin M Nemoto, Denis E Bragin

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Academic radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alex O TrofimovDepartment of Neurological Diseases, Privolzhsky Research Medical University, Nizhny Novgorod, Russia (A.O.T., K.A.T.); Department of Physiology, Saratov State University, Saratov, Russia (A.O.T., O.V.S.G.). Electronic address: xtro7@mail.ru.
Kseniia A TrofimovaDepartment of Neurological Diseases, Privolzhsky Research Medical University, Nizhny Novgorod, Russia (A.O.T., K.A.T.).
Oxana V Semyachkina-GlushkovskayaDepartment of Physiology, Saratov State University, Saratov, Russia (A.O.T., O.V.S.G.).
Edwin M NemotoDepartment of Neurology, University of New Mexico School of Medicine, Albuquerque, New Mexico (E.M.N., D.E.B.).
Denis E BraginDepartment of Neurology, University of New Mexico School of Medicine, Albuquerque, New Mexico (E.M.N., D.E.B.); Lovelace Biomedical Research Institute, Albuquerque, New Mexico (D.E.B.). Electronic address: dbragin@salud.unm.edu.

Funding

University of New Mexico (UNM) Center for Brain Recovery and RepairP20GM109089 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI SHUTTLEWORTH, CLAUDE W · 2015 to 2024
$22.7M
Brain Injury Treatment by Modulation of Hemodynamics With Blood Soluble Drag Reducing MoleculesR01NS112808 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BRAGIN, DENIS E. · 2019 to 2023
$2.1M
Stroke Treatment by Modulation of Hemodynamics with Drag Reducing MoleculesR21NS091600 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BRAGIN, DENIS E. · 2015 to 2016
$423k
NIGMS NIH HHS P20 GM109089NINDS NIH HHS R01 NS112808NINDS NIH HHS R21 NS091600
6 · The paper itself

Abstract

purposeThe aim of our study was to compare net-water uptake (NWU), which serves as a quantitative imaging marker of cerebral edema, with brain oxygen status and cerebral microcirculation changes in posttraumatic peri-ischemic foci (PIF) in severe traumatic brain injury (sTBI) patients. MATERIALS AND

methods89 sTBI patients (women 35; men 54, age 37 years [25;47]) with unilateral frontal/frontotemporal lesions were included in this retrospective, non-randomized, single-center study. Cerebral blood flow (CBF), cerebral blood volume (CBV), delay time (DT), time to maximum contrast concentration (Tmax), and mean transit time (MTT) were measured in PIF and determined using dynamic perfusion computed tomography (PCT) in the first 2 days after trauma and admission. NWU in PIF was calculated using non-contrast CT. Cerebral oxygenation (SctO

resultsPenumbra/core ratio median (mismatch ratio) was 2.12 (1.78; 2.87). In PIF, SctO

conclusionBrain edema in PIF was significantly associated with cerebral microcirculation and cerebral O

Indexed as

Brain EdemaBrain Injuries, TraumaticAdultCerebrovascular CirculationFemaleHumansMaleMicrocirculationMiddle AgedRetrospective StudiesSpectroscopy, Near-InfraredTomography, X-Ray ComputedComputed TomographyNet Water UptakeNIRSPosttraumatic IschemiaTraumatic brain injury

Identifiers

PMID40816923
PMCPMC12449298

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.