Evidence map›Paper›PMID 40816852›Full record

ArticleJACC. Case reports2025

Severe Aortic Valve Stenosis During Pregnancy: Role of Multidisciplinary Pregnancy Heart Team to Guide Decision-Making.

Lindsay A Gallagher, Shuo Li, Zeynep Alpay Savasan, Thomas Schwann, Saavia S Girgla

Abstract readCase Reports
In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lindsay A GallagherOakland University William Beaumont School of Medicine, Rochester, Michigan, USA. Electronic address: lgallagher@oakland.edu.
Shuo LiDepartment of Internal Medicine, Corewell Health William Beaumont University Hospital, Royal Oak, Michigan, USA.
Zeynep Alpay SavasanDepartment of Maternal Fetal Medicine, Corewell Health William Beaumont University Hospital, Royal Oak, Michigan, USA.
Thomas SchwannDepartment of Cardiovascular Surgery, Corewell Health William Beaumont University Hospital, Royal Oak, Michigan, USA.
Saavia S GirglaDepartment of Cardiovascular Medicine, Corewell Health William Beaumont University Hospital, Royal Oak, Michigan, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPregnant women with underlying cardiovascular disease are at an increased risk of maternal-fetal morbidity and mortality especially in the setting of symptomatic stenotic valvular heart disease. CASE SUMMARY: A 35-year-old female at 17 weeks gestation presented to the emergency department with exertional dyspnea for 3 months and was diagnosed with decompensated heart failure. Echocardiogram demonstrated left ventricular ejection fraction of 45% with severe aortic valve stenosis and moderate aortic regurgitation. A multidisciplinary pregnancy heart team recommended urgent surgical aortic valve replacement prior to fetal maturity. DISCUSSION: Hemodynamic changes in pregnancy, such as increased blood volume and heart rate, may unmask asymptomatic cardiovascular disease. Specifically, increased blood volume during pregnancy is poorly tolerated in patients with stenotic valvular disease and may result in NYHA functional class III or IV heart failure. TAKE-HOME MESSAGE: Cardiovascular comorbidities in pregnant women require careful evaluation by a multidisciplinary pregnancy heart team to determine optimal timing and approach for intervention.

Indexed as

acute heart failureaortic valvecardiovascular diseasecomputed tomographypregnancyvalve replacement

Identifiers

PMID40816852
PMCPMC12462078

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.