Identification and Successful Treatment of Intrahepatic Cholangiocarcinoma After Fontan Procedure.

Matthew W Minick, Ashley J Limkemann, Sean G Kelly, Giovanni M Lujan, Curt J Daniels, William H Marshall V

Abstract readCase Reports

In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Matthew W MinickThe Ohio State University College of Medicine, Columbus, Ohio, USA.

Ashley J LimkemannDivision of Transplant Surgery, Department of Surgery, The Wexner Medical Center at the Ohio State University, Columbus, Ohio, USA.

Sean G KellyDivision of Hepatology, Gastroenterology and Nutrition, Department of Internal Medicine, The Wexner Medical Center at the Ohio State University, Columbus, Ohio, USA.

Giovanni M LujanDivision of Surgical Pathology, Department of Pathology, The Wexner Medical Center at the Ohio State University, Columbus, Ohio, USA.

Curt J DanielsDivision of Cardiovascular Medicine, Department of Internal Medicine, The Wexner Medical Center at the Ohio State University, Columbus, Ohio, USA; Nationwide Children's Hospital, The Heart Center, Columbus, Ohio, USA.

William H Marshall VDivision of Cardiovascular Medicine, Department of Internal Medicine, The Wexner Medical Center at the Ohio State University, Columbus, Ohio, USA; Nationwide Children's Hospital, The Heart Center, Columbus, Ohio, USA. Electronic address: William.marshall@osumc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFontan-associated liver disease (FALD) increases the risk of malignant liver complications in patients with Fontan circulation. CASE SUMMARY: We present a case of intrahepatic cholangiocarcinoma in a patient with Fontan circulation, diagnosed using targeted biopsy for a hepatic lesion found during heart transplant evaluation. The patient underwent successful tumor resection with adjuvant chemotherapy and has been recurrence-free for 2 years. DISCUSSION: Although hepatocellular carcinoma (HCC) is more common in patients with FALD, this is the fifth published case of intrahepatic cholangiocarcinoma in a patient with Fontan circulation, with the longest reported follow-up after successful treatment. Targeted liver biopsy was integral in the diagnosis to provide appropriate treatment. TAKE-HOME MESSAGES: Patients with FALD are at risk for both HCC and intrahepatic cholangiocarcinoma. A low threshold for targeted biopsy is important for evaluation of new liver lesions in patients with FALD, even if the most likely diagnosis is HCC.

Indexed as

FALDFontan associated liver diseaseFontan circulationintrahepatic cholangiocarcinoma

Identifiers

PMID40816826

DOI10.1016/j.jaccas.2025.104649

PMCPMC12462095

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.