Evidence map›Paper›PMID 40816824›Full record

ArticleJACC. Case reports2025

ECPELLA as a Bridge to Unexpected Myocardial Recovery in a Patient in Refractory Cardiogenic Shock.

Andrew H Nguyen, Behnam N Tehrani, Alexander G Truesdell, Carolyn M Rosner, Hala Moukhachen, Mehul Desai, Christopher King, Ramesh Singh, Ilan Vavilin, Shashank S Sinha

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andrew H NguyenDepartment of Cardiovascular Disease, Inova Schar Heart and Vascular, Inova Fairfax Medical Campus, Falls Church, Virginia, USA. Electronic address: https://twitter.com/AndrewNguyen_DO.
Behnam N TehraniDepartment of Cardiovascular Disease, Inova Schar Heart and Vascular, Inova Fairfax Medical Campus, Falls Church, Virginia, USA.
Alexander G TruesdellDepartment of Cardiovascular Disease, Inova Schar Heart and Vascular, Inova Fairfax Medical Campus, Falls Church, Virginia, USA; Department of Cardiovascular Disease, Virginia Heart, Falls Church, Virginia, USA.
Carolyn M RosnerDepartment of Cardiovascular Disease, Inova Schar Heart and Vascular, Inova Fairfax Medical Campus, Falls Church, Virginia, USA.
Hala MoukhachenDepartment of Medical Critical Care, Inova Schar Heart and Vascular, Falls Church, Virginia, USA.
Mehul DesaiDepartment of Medical Critical Care, Inova Schar Heart and Vascular, Falls Church, Virginia, USA.
Christopher KingDepartment of Medical Critical Care, Inova Schar Heart and Vascular, Falls Church, Virginia, USA.
Ramesh SinghDepartment of Cardiothoracic Surgery, Inova Schar Heart and Vascular, Falls Church, Virginia, USA.
Ilan VavilinDepartment of Cardiovascular Disease, Inova Schar Heart and Vascular, Inova Fairfax Medical Campus, Falls Church, Virginia, USA.
Shashank S SinhaDepartment of Cardiovascular Disease, Inova Schar Heart and Vascular, Inova Fairfax Medical Campus, Falls Church, Virginia, USA. Electronic address: Shashank.Sinha@inova.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiogenic shock (CS) is a complex, multifactorial syndrome with substantial morbidity and mortality. Despite neutral results from randomized controlled trials, venoarterial extracorporeal membrane oxygenation (VA-ECMO) may be reasonable for select patients with refractory CS. A 37-year-old woman with morbid obesity and dilated nonischemic cardiomyopathy presented with Society of Cardiovascular Angiography and Intervention stage D biventricular CS, requiring vasopressor support and emergent escalation to ECPELLA, the combination of VA-ECMO and Impella (Abiomed), as a bridge to decision. She was provisionally accepted for a left ventricular assist device as destination therapy; however, her hospital course was complicated by cardiac arrest, recurrent ventricular tachycardia, lung collapse, and progressive renal failure. Planned surgical intervention was deferred as surveillance imaging demonstrated partial native myocardial recovery. The patient was eventually weaned off all support and discharged home. ECPELLA, as compared with VA-ECMO alone, has been associated with improved survival, and this case highlights its potential role as a bridge to myocardial recovery.

Indexed as

cardiogenic shockECPELLAImpellaLVADLV unloadingmyocardial recoverytemporary mechanical circulatory supportVA-ECMO

Identifiers

PMID40816824
PMCPMC12461884

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.