ArticleJournal of neuroscience methods2025
Probabilistic normative maps of the corticospinal and cortico-reticulospinal tracts in streamline and volumetric formats.
Article in Journal of neuroscience methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Role of Contralesional Corticoreticulospinal Tract Compensation in Walking Function After Stroke.Brain and behavior · 2026Trial
- Progressive motor impairment from intracerebral critical demyelinating lesions.Journal of neurology · 2026Article
- A narrative review of motor control dual pathways: the corticospinal and reticulospinal tracts in synergy and differentiation.Frontiers in neuroanatomy · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundNormative maps of brain tracts are key tools for assessing the extent of tract injury and plasticity after brain lesions such as stroke. The conventional procedure for tract mapping reduces diffusion tractography streamlines to a volumetric image before warping them to a standard coordinate space. Unfortunately, this volumetric reduction discards information about tract connectivity across voxels, complicating estimation of tract injury from the resulting map. This issue could be addressed by using a streamline-based tract map, but prior efforts to do so using group-based tractography have not accounted for individual variability, and thus are at risk of underestimating tract extent. NEW
methodDirect streamline normalization (DSN) directly warps individual tractography streamlines to a standard coordinate space, which can be pooled across individuals to account for individual variability. Here, DSN was used to create normative tract maps for the first time.
resultsNovel probabilistic maps of the corticospinal tract (CST) and cortico-reticulospinal tract (CRST) were generated in streamline format using DSN. COMPARISON WITH EXISTING
methodsCompared with group-based tractography, tract maps generated with DSN had 3.1-5.2 times greater volume, 1.0-1.5 times greater mean diameter and 7.8-15.3 times greater cortical origin area.
conclusionsDSN produces tract maps with more accurate representation of axonal geometry than the conventional procedure and greater incorporation of individual variability than group-based tractography, likely resulting in larger maps. Future studies can use the CST and CRST maps generated here to optimize tract injury and plasticity measurements, which may provide an improved understanding of motor impairment and recovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.