Evidence map›Paper›PMID 40816501›Full record

ArticleLife sciences2025

Gastric dilation following vertical sleeve gastrectomy reflects adaptive stem cell-driven regeneration without association with weight regain or increased cancer risk.

Oluwatosin Asunloye, Ruchita Shelat, McKenzie McCarthy, Britney Le, Rima Patel, Amit Elad, Haya Benhayon, Rachel Ben-Haroush Schyr, Danny Ben-Zvi, Ki-Suk Kim

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Article in Life sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Oluwatosin AsunloyeDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN, USA.
Ruchita ShelatDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN, USA.
McKenzie McCarthyDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN, USA.
Britney LeDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN, USA.
Rima PatelDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN, USA.
Amit EladDepartment of Developmental Biology and Cancer Research, The Institute for Medical Research Israel Canada, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Haya BenhayonDepartment of Developmental Biology and Cancer Research, The Institute for Medical Research Israel Canada, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Rachel Ben-Haroush SchyrDepartment of Developmental Biology and Cancer Research, The Institute for Medical Research Israel Canada, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Danny Ben-ZviDepartment of Developmental Biology and Cancer Research, The Institute for Medical Research Israel Canada, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Ki-Suk KimDepartment of Physiology, University of Tennessee Health Science Center, Memphis, TN, USA. Electronic address: kkim50@uthsc.edu.

Funding

The role of enteroendocrine cell differentiation in the success of bariatric surgeryK01DK129367 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI KIM, KI SUK · 2021 to 2025
$672k
NIDDK NIH HHS K01 DK129367
6 · The paper itself

Abstract

aimsBariatric surgery is the most effective intervention for sustained weight loss and the improvement of obesity-related comorbidities. Among these procedures, vertical sleeve gastrectomy (VSG) is the most commonly performed worldwide. Yet, post-VSG gastric dilation has been hypothesized to contribute to failure in weight loss or even weight regain by increasing the secretion of ghrelin, an orexigenic hormone primarily produced in the stomach. However, the relationship between gastric dilation, its underlying mechanism, and its clinical implications remain unclear. MATERIALS AND

methodsTo investigate this, we utilized both a mouse model of VSG and corpus epithelial samples from patients who had undergone VSG. KEY

findingsUsing a diet-induced obese mouse model, we found that VSG leads to significant gastric remodeling, yet neither stomach expansion nor increased ghrelin secretion correlated with weight regain. Single-cell RNA sequencing of corpus epithelial cells from VSG patients further revealed an associated with epithelial regeneration, marked by gastric stem cell expansion and upregulation of repair-associated genes. RNA sequencing also showed enhanced stem cell activity alongside upregulation of tumor suppressor genes and long non-coding RNAs, suggesting a potential protective mechanism against gastric cancer despite rapid cellular proliferation. SIGNIFICANCE: These findings challenge the assumption that gastric dilation is a predictor of poor surgical outcomes and instead suggest that it is an adaptive response to VSG, offering new insights into post-VSG gastric remodeling.

Indexed as

GastrectomyGastric DilatationRegenerationStem CellsStomach NeoplasmsWeight GainAnimalsBariatric SurgeryFemaleGhrelinHumansMaleMiceMice, Inbred C57BLMiddle AgedObesityGhrelinBariatric surgeryCarcinogenesisCell proliferationGastrectomyGastric dilatationGhrelinStem cellWeight loss

Identifiers

PMID40816501
PMCPMC13210394

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.