Evidence map›Paper›PMID 40816349›Full record

ArticlePreventive medicine2025

Adverse childhood experiences, resilience, and substance use during early pregnancy.

Kelly C Young-Wolff, Mariah S Wood, Sara R Adams, Monique B Does, Deborah Ansley, Carley Castellanos, Maria T Koshy, Carey R Watson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Preventive medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kelly C Young-WolffDivision of Research, Kaiser Permanente Northern California, Pleasanton, CA, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA. Electronic address: Kelly.c.young-wolff@kp.org.
Mariah S WoodDivision of Research, Kaiser Permanente Northern California, Pleasanton, CA, USA.
Sara R AdamsDivision of Research, Kaiser Permanente Northern California, Pleasanton, CA, USA.
Monique B DoesDivision of Research, Kaiser Permanente Northern California, Pleasanton, CA, USA.
Deborah AnsleyRegional Offices, Kaiser Permanente Northern California, Pleasanton, CA, USA.
Carley CastellanosRegional Offices, Kaiser Permanente Northern California, Pleasanton, CA, USA.
Maria T KoshyRegional Offices, Kaiser Permanente Northern California, Pleasanton, CA, USA.
Carey R WatsonObstetrics and Gynecology, Kaiser Permanente, Walnut Creek, CA, USA.

Funding

Modes of Cannabis Administration and Polysubstance Use among Women Before and During PregnancyR01DA058201 · NIDA · KAISER FOUNDATION RESEARCH INSTITUTE · PI Kelly Corinne Young-Wolff · 2023 to 2026
$2.6M
Identifying Risk Factors for Prenatal Substance and Polysubstance UseK01DA043604 · NIDA · KAISER FOUNDATION RESEARCH INSTITUTE · PI YOUNG-WOLFF, KELLY CORINNE · 2017 to 2021
$907k
NIDA NIH HHS K01 DA043604NIDA NIH HHS R01 DA058201
6 · The paper itself

Abstract

objectiveAdverse childhood experiences (ACEs) are common risk factors for unhealthy behaviors and poor health outcomes throughout the life course, but their relationship with prenatal substance use is understudied. This retrospective cohort study included 44,284 patients with pregnancies between January 1, 2022, and June 28, 2024, in a large healthcare system in Northern California, United States of America with universal screening for ACEs, resilience, and substance use during early pregnancy.

methodsMultivariable regression models examined the relationship between ACEs and prenatal substance use and tested whether resilience moderated these associations.

resultsPregnant individuals with a greater number of ACEs had lower resilience, were younger, more likely to be Black, Non-Hispanic White, or Hispanic, and live in an area with greater neighborhood deprivation. In adjusted models, compared to those without ACEs, those with ACEs had a higher adjusted prevalence of prenatal alcohol use, cannabis use, nicotine use, pharmaceutical opioid use, stimulant use, and multiple substance use. Low resilience was independently associated with an increased prevalence of prenatal substance use.

conclusionsResults indicate that routine screening for ACEs may help identify pregnant individuals at risk for prenatal substance use, allowing for earlier linkage to resources and potentially improved maternal and child outcomes.

Indexed as

Adverse Childhood ExperiencesPregnancy ComplicationsResilience, PsychologicalSubstance-Related DisordersAdultCaliforniaFemaleHumansPregnancyPrevalenceRetrospective StudiesRisk FactorsACEsPregnancyResilienceSubstance use

Identifiers

PMID40816349
PMCPMC12424441

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.