ReviewStem cell reports2025
Adult hippocampal neurogenesis: New avenues for treatment of brain disorders.
Review in Stem cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Reconciling the neurogenic hypothesis of depression with recent advances in adult hippocampal neurogenesis research in humans.Molecular psychiatry · 2026Review
- Broca's area, responsible for speech production, is regulated by lung function.Neural regeneration research · 2026Article
- Deiodinase 3 Deficiency Impairs Hippocampal and Lateral Ventricle Neurogenesis in Middle-Aged Female Mice.International journal of molecular sciences · 2026Article
- Neural stem cells as potential mediators of prenatal dietary stress through epigenetic mechanisms.Stem cell reports · 2026Article
- Metabolic Brain Disorders: Prodromes, Symptoms, and Syndromes.International journal of molecular sciences · 2026Review
- Humanised Environmental Enrichment: Spatial Effects of Cities and Buildings on Adult Hippocampal Neurogenesis in Humans.International journal of molecular sciences · 2026Review
- The Converging Effects of Different Categories of Antidepressants on the Brain: A Systematic Meta-Analysis of Public Transcriptional Profiling Data from the Hippocampus and Cortex.bioRxiv : the preprint server for biology · 2026Article
- Pathophysiological roles of neural stem cells in neuropsychiatric diseases: from plasticity to pharmacological targeting.Acta pharmacologica Sinica · 2026Review
- Article
- Neuroprotection and Neuroplasticity Through Natural Bioactive Compounds: An Editorial Overview.International journal of molecular sciences · 2026Article
- Mechanobiology of hippocampal neurogenesis: directing neural stem cell fate through physical cues.Frontiers in molecular neuroscience · 2026Review
- Decreased hippocampal neurogenesis and post-stroke depression.Frontiers in psychiatry · 2026Review
- Comparative analysis of maze complexity: implications for adult hippocampal neurogenesis.Frontiers in neuroscience · 2026Article
- The hippocampal subgranular zone neurogenic niche: a modular perspective on neural stem cell regulation.Frontiers in cellular neuroscience · 2026Review
- Role of Reactive Astrocytes and Microglia: Wnt/β-Catenin Signaling in Neuroprotection and Repair in Parkinson's Disease.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurogenesis, the biological process of forming new neurons, was traditionally believed to occur only during embryonic stages in the mammalian central nervous system for a long time. Over the past few decades, due to the development of new techniques and the accumulation of supportive evidence, adult neurogenesis is now accepted as the one of the most robust forms of plasticity in the adult brain, which contributes to physiological function as well as a range of neurological or psychiatric disorders. In this review, we mainly concentrate on adult neurogenesis in the hippocampus, the most likely neurogenic niche with significant roles in various brain functions. We begin by summarizing the current fundamental knowledge of adult hippocampal neurogenesis including proliferation, differentiation, maturation, and synapse formation of neural stem cells. We then focus on the potential roles of these adult-born neurons and their contribution to learning and memory behaviors and their relevance to various diseases. Furthermore, we review regulatory mechanisms governing adult hippocampal neurogenesis, including local environmental cues, multiple molecular signaling pathways, and neural network activities. We also discuss possible therapeutic strategies and targets that can be leveraged for future clinical translations. Finally, given the substantial progress in the field of regenerative medicine aimed at harnessing the multipotent resident cells for brain repair, we address remaining challenges and propose our perspectives on future directions for treating central nervous system disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.