Evidence map›Paper›PMID 40816247›Full record

ArticleEuropean journal of obstetrics, gynecology, and reproductive biology2025

Patient-centered management of heavy menstrual bleeding while on anticoagulation: A survey study.

Benjamin Barnett, Rushad Patell, Dana Angelini, Leben Tefera, Jordan K Schaefer, Ang Li, Alejandra Gutierrez Bernal, Shruti Chaturvedi, Anjlee Mahajan, Leslie Lake and 2 more

Abstract read
In one paragraph

Article in European journal of obstetrics, gynecology, and reproductive biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Benjamin BarnettBeth Israel Deaconess Medical Center, Boston, MA, USA.
Rushad PatellBeth Israel Deaconess Medical Center, Boston, MA, USA.
Dana AngeliniCleveland Clinic, Cleveland, OH, USA.
Leben TeferaCleveland Clinic, Cleveland, OH, USA.
Jordan K SchaeferUniversity of Michigan, Ann Arbor, MI, USA.
Ang LiBaylor College of Medicine, Houston, TX, USA.
Alejandra Gutierrez BernalUniversity of Minnesota, Minneapolis, MN, USA.
Shruti ChaturvediJohns Hopkins School of Medicine, Baltimore, MD, USA.
Anjlee MahajanUniversity of California Davis, Sacramento, CA, USA.
Leslie LakeNational Blood Clot Alliance, Philadelphia, PA, USA.
Jori MayUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Anna L ParksUniversity of Utah Health, Salt Lake City, UT, USA. Electronic address: anna.parks@hsc.utah.edu.

Funding

Targeting silent cerebral infarction to improve long-term neurologic outcomes in immune thrombotic thrombocytopenic purpura (iTTP)R00HL172303 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Shruti Chaturvedi · 2024 to 2026
$1.3M
Advancing patient-centered decision making in older adults with venous thromboembolismK76AG083304 · NIA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Anna L Parks · 2024 to 2026
$729k
NHLBI NIH HHS R00 HL172303NIA NIH HHS K76 AG083304
6 · The paper itself

Abstract

backgroundNearly three-quarters of women experience heavy menstrual bleeding (HMB) during anticoagulation treatment for venous thromboembolism (VTE). HMB can lead to medical interventions, impact school or work and diminish quality of life (QOL). While there are several management options for HMB in patients with VTE, we lack information on how patients approach HMB treatment decisions.

objectivesWe examined patients' experience with, perceptions of, and preferences for treatment of HMB while on anticoagulation.

methodsClinicians and patient advocates developed a web-based survey that was distributed via patient advocacy organizations and social media between May and June 2024, targeting participants 18 years or older who menstruate with a history of VTE and self-reported HMB.

resultsA total of 387 participants completed the survey. All participants (100%) reported a history of HMB, and half (50%) experienced HMB while on anticoagulation for greater than twelve months. The majority (86%) reported a negative effect on their QOL. Only 43% of patients reported receiving treatment for HMB, with 10% reporting temporarily holding anticoagulation due to HMB. Approximately a fifth of respondents associated low-risk treatment modalities with thrombosis, including progesterone-only oral contraceptives (21%), implants (18%), and intrauterine devices (progesterone 18%, copper 17%). The majority (83%) of patients identified thrombotic risk as the most important factor when considering treatment options.

conclusionsHMB is under-reported and undertreated in patients on anticoagulation. Patients have important misconceptions about treatment options; prioritized recurrent thrombosis risk when weighing treatment options; and preferred a multidisciplinary, multimodal approach. These findings should inform interventions to improve patient education and decision support for HMB on anticoagulants.

Indexed as

AnticoagulantsMenorrhagiaPatient-Centered CareVenous ThromboembolismAdultFemaleHumansMiddle AgedPatient PreferenceQuality of LifeSurveys and QuestionnairesYoung AdultAnticoagulantsAdultAnticoagulantsContraceptivesFemaleHumansIntrauterine devicesMenorrhagiaProgesteroneQuality of lifeThrombosisVenous thromboembolism

Identifiers

PMID40816247
PMCPMC12424477

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.