ArticleSocial science & medicine (1982)2025
Life course socioeconomic disadvantage and persistent infection burden: Links to cellular immunosenescence in U.S. young adults.
Jennifer Momkus, Kathleen Mullan Harris, Y Claire Yang, Chantel L Martin, Jessie K Edwards, Allison E Aiello
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In one paragraphArticle in Social science & medicine (1982), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
6 authors.
Jennifer MomkusDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina Chapel Hill, United States; Carolina Population Center, University of North Carolina Chapel Hill, United States. Electronic address: jmomkus@email.unc.edu.
Kathleen Mullan HarrisCarolina Population Center, University of North Carolina Chapel Hill, United States; Department of Sociology, University of North Carolina Chapel Hill, United States.
Y Claire YangCarolina Population Center, University of North Carolina Chapel Hill, United States; Department of Sociology, University of North Carolina Chapel Hill, United States; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, United States.
Chantel L MartinDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina Chapel Hill, United States; Carolina Population Center, University of North Carolina Chapel Hill, United States.
Jessie K EdwardsDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina Chapel Hill, United States; Carolina Population Center, University of North Carolina Chapel Hill, United States.
Allison E AielloRobert N. Butler Columbia Aging Center, Columbia University, United States; Department of Epidemiology, Mailman School of Public Health, Columbia University, United States.
Funding
Wave IV Data CollectionP01HD031921 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HARRIS, KATHLEEN MULLAN · 1994 to 2020
$86.1MNational Longitudinal Study of Adolescent to Adult Health (Add Health): Wave VII Core ProjectU01AG071448 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Allison E Aiello, Lauren M Gaydosh · 2021 to 2026
$40.2MNational Longitudinal Study of Adolescent to Adult Health (Add Health): Wave VI Cognition and Early Risk Factors for Dementia ProjectU01AG071450 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AIELLO, ALLISON E, HUMMER, ROBERT A · 2021 to 2025
$16.2MCarolina Population CenterR24HD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MORGAN, SAMUEL PHILIP · 2005 to 2014
$10.0MResearch Services CoreP2CHD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KAREN B GUZZO · 2015 to 2026
$9.6MFrom Biological to Social Processes: Interdisciplinary Training in Life Course ResearchT32HD091058 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT A HUMMER, Amanda L Thompson · 2017 to 2026
$4.3MLife Course Process of Alzheimer's Disease: Sex Difference and Biosocial MechanismsR01AG057800 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YANG, YANG CLAIRE · 2017 to 2021
$3.6MThe Add Health Epigenome Resource: Life course stressors and epigenomic modifications in adulthoodR01MD013349 · NIMHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AIELLO, ALLISON E, HARRIS, KATHLEEN MULLAN · 2018 to 2022
$3.5MNIA NIH HHS R01 AG057800NIA NIH HHS U01 AG071448NIA NIH HHS U01 AG071450NICHD NIH HHS P01 HD031921NICHD NIH HHS P2C HD050924NICHD NIH HHS R24 HD050924NICHD NIH HHS T32 HD091058NIMHD NIH HHS R01 MD013349
6 · The paper itselfAbstract
backgroundSocioeconomic status (SES) disadvantage shapes exposure to persistent infections and immune aging, but its life-course effects remain understudied. Early adulthood is a crucial period, as immune aging may begin before clinical signs appear.
methodsData from the National Longitudinal Study of Adolescent to Adult Health (Add Health) were used to assess SES disadvantage across adolescence (Wave I) and young adulthood (Wave IV). Four life-course SES disadvantage trajectories were defined: non-disadvantaged, upward mobility, downward mobility, and persistent disadvantage. Outcomes included dried blood spot-based seropositivity and IgG antibody levels for Cytomegalovirus (CMV), Herpes simplex virus type 1 (HSV-1), Epstein-Barr virus (EBV), and Helicobacter pylori (H. Pylori) in young adulthood, and DNA-methylation-based CD4
resultsIn young adulthood, persistent SES disadvantage was associated with higher odds of CMV, HSV-1, and H. Pylori infection (e.g. H. Pylori OR = 2.2, 95 % CI: 1.7, 2.9) and higher antibody levels (e.g. HSV-1 β = 1.4, 95 % CI: 0.9, 1.9). In early midlife, it was associated with CMV seropositivity and antibody levels (OR = 1.8, 95 % CI: 1.4-2.3; β = 13.0, 95 % CI: 7.4, 18.7), and elevated CD4
conclusionsPersistent SES disadvantage was consistently associated with higher infection burden and more aged immune cell profiles before midlife. Understanding this link is key for addressing health disparities.
Indexed as
ImmunosenescenceSocial ClassAdolescentAdultCytomegalovirus InfectionsFemaleHelicobacter InfectionsHumansLongitudinal StudiesMaleSocioeconomic Disparities in HealthSocioeconomic FactorsUnited StatesYoung Adult
Identifiers
PMID40816217
PMCPMC12404219
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