Evidence map›Paper›PMID 40816047›Full record

ArticleEnvironment international2025

Maternal factors associated with plasma concentrations of endocrine-disrupting persistent organic pollutants including PFAS among Hispanic women from pregnancy to the post-delivery period.

Chenyu Qiu, Wu Chen, Ni Kang, Jiawen Liao, Nosa Osazuwa, Caleb Schimke, Andreas Sjodin, Antonia M Calafat, Julianne C Botelho, Dean Jones and 3 more

Abstract read
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In one paragraph

Article in Environment international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chenyu QiuDepartment of Population and Public Health Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Wu ChenDepartment of Population and Public Health Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Ni KangDepartment of Population and Public Health Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Jiawen LiaoDepartment of Population and Public Health Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Nosa OsazuwaDepartment of Population and Public Health Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Caleb SchimkeDepartment of Population and Public Health Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Andreas SjodinDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Antonia M CalafatDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Julianne C BotelhoDivision of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Dean JonesDepartment of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Thomas BuchananDepartment of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA.
Anny H XiangDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA.
Zhanghua ChenDepartment of Population and Public Health Sciences, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA. Electronic address: zhanghuc@usc.edu.

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4M
PATHOGENESIS OF TYPE 2 DIABETES IN LATINO WOMENR01DK046374 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUCHANAN, THOMAS A · 1993 to 2006
$2.6M
The Long-term Influence of Persistent Organic Pollutants Exposure During and After Pregnancy on Metabolic Decline in Women After Pregnancies Complicated by Gestational DiabetesR01ES032247 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, ZHANGHUA · 2020 to 2023
$1.9M
Metabolomic Signatures Linking Air Pollution, Obesity and DiabetesR00ES027870 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, ZHANGHUA · 2019 to 2021
$747k
NIDDK NIH HHS P30 DK017047NIDDK NIH HHS R01 DK046374NIEHS NIH HHS P30 ES007048NIEHS NIH HHS R00 ES027870NIEHS NIH HHS R01 ES032247
6 · The paper itself

Abstract

objectiveUpon exposure, persistent organic pollutants (POPs) accumulate in the body. One-time point measurement of POPs plasma concentrations can reflect body burden. This study aimed to assess whether maternal factors including age, breastfeeding, and weight, influence changes in plasma concentrations of POPs in women during critical periods of physical changes from pregnancy to 15-60 months after delivery.

methodsNinety-nine self-identified Hispanic women who were diagnosed with gestational diabetes mellitus (GDM) and originally enrolled in the GDM cohort study in 1993-1995 were included in this study. Plasma concentrations of 21 polychlorinated biphenyls (PCBs), 7 organochlorine pesticides (OCPs), 5 polybrominated diphenyl ethers (PBDEs), 2,2',4,4',5,5'-hexabromobiphenyl (BB153), and 6 per- and polyfluoroalkyl substances (PFAS) were quantified in archived samples collected in the 3rd trimester of pregnancy and post-delivery (81.8 % were from 15 months after delivery, the rest were from 30-60 months post-delivery). Multivariable linear regression was used to analyze associations of maternal factors such as weight change, age and breastfeeding status after delivery with changes in POPs concentrations from 3rd trimester of pregnancy to the post-delivery visit.

resultsFrom pregnancy to post-delivery period, plasma concentrations of 4 PBDEs and 6 PFAS significantly increased, while those of 20 PCBs, all OCPs and BB153 significantly decreased (all p-values < 0.05). Additionally, older age and breastfeeding after delivery were significantly associated with greater reduction in concentrations of PCBs, OCPs, and BB153 from pregnancy to the post-delivery period, whereas weight loss was associated with a smaller reduction in these POPs (all p-values < 0.05). Post-delivery weight gain was associated with greater elevation in concentrations of 2-(N-methylperfluorooctane sulfonamido) acetate and branched isomers of perfluorooctane sulfonate.

conclusionConcentrations of PCBs, OCPs, and BB153 declined more in older women and those who breastfed their newborns, whereas the decline was smaller among women who lost more weight after delivery.

Indexed as

Endocrine DisruptorsFluorocarbonsMaternal ExposurePersistent Organic PollutantsAdultBreast FeedingCohort StudiesDiabetes, GestationalFemaleHalogenated Diphenyl EthersHispanic or LatinoHumansHydrocarbons, ChlorinatedPesticidesPolychlorinated BiphenylsPostpartum PeriodEndocrine DisruptorsFluorocarbonsHalogenated Diphenyl EthersHydrocarbons, ChlorinatedPersistent Organic PollutantsPesticidesPolychlorinated BiphenylsBreastfeedingMaternal agePersistent organic pollutantsPFASWeight

Identifiers

PMID40816047
PMCPMC12651189

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.