ArticleBlood advances2025
Arterial human blood flow can be stopped by cables of VWF and platelets without coagulation.
Article in Blood advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- From biomimicry to clinical actionability: rethinking high-shear thrombosis as a mechanobiological system.Current opinion in hematology · 2026Review
- Von Willebrand factor A1 blockade prevents platelet-mediated sustained occlusion for the treatment of arterial thrombosis.Communications biology · 2026Article
- The clot thickens: transverse cables under high shear flow.Blood advances · 2025Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
abstractArterial thrombi formed under high shear rates (∼15 000/s) must withstand substantial forces to occlude arteries, as occurs in myocardial infarction or ischemic stroke, driving the need to understand the structural features responsible for their strength. We used scanning electron microscopy and immunofluorescence microscopy to characterize the structure of in vitro high-shear thrombi. We show that the occlusive portion of the thrombus consists of a thick, transverse cable spanning the channel width. The cable is made of hundreds of parallel strings of platelets joined by yarns of von Willebrand factor (VWF) fibers identified by immunofluorescence microscopy. The elements composing the occlusive structure-cable, strings, yarns, and fibers, listed in hierarchical order-are oriented in the direction of tension to confer high breakage strength and stability to resist the upstream pressure. This structural hierarchy supports VWF-VWF bonding as a potential new target for the prevention and lysis of occlusive arterial thrombi.
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