Evidence map›Paper›PMID 40815686›Full record

ArticleAmerican journal of respiratory and critical care medicine2025

Active Antigen-Specific Adaptive Immune Responses Are Shared among Patients with Progressive Fibrotic Interstitial Lung Disease.

Tania E Velez, Young Me Yoon, Vaibhav Upadhyay, Sara E Vazquez, Cathryn T Lee, Kavitha C Selvan, Christopher S Law, Kelly M Blaine, Maile K Hollinger, Donna M Decker and 15 more

Abstract read
In one paragraph

Article in American journal of respiratory and critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. To B or Not to B: Germinal Center Responses in Progressive Fibrotic Interstitial Lung Disease.American journal of respiratory and critical care medicine · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors.

Tania E VelezDivision of Pulmonary and Critical Care Medicine, Department of Medicine, and.ORCID 0000-0002-9333-1356
Young Me YoonCommittee on Immunology and Section of Pulmonary and Critical Care Medicine, Department of Medicine.ORCID 0000-0001-8312-7864
Vaibhav UpadhyayDepartment of Medicine, University of California, San Francisco, San Francisco, California.ORCID 0000-0002-7652-1043
Sara E VazquezUniversity of California, San Francisco and Chan Zuckerberg Biohub, San Francisco, California; and.ORCID 0000-0002-0601-7001
Cathryn T LeeSection of Pulmonary and Critical Care Medicine, Department of Medicine, and.ORCID 0000-0002-0963-7505
Kavitha C SelvanSection of Pulmonary and Critical Care Medicine, Department of Medicine, and.ORCID 0000-0002-0988-0222
Christopher S LawDepartment of Medicine, University of California, San Francisco, San Francisco, California.ORCID 0009-0005-4516-3844
Kelly M BlaineSection of Pulmonary and Critical Care Medicine, Department of Medicine, and.ORCID 0009-0000-5931-3229
Maile K HollingerDivision of Pulmonary and Critical Care Medicine, Department of Medicine, and.ORCID 0000-0001-8303-6188
Donna M DeckerSection of Pulmonary and Critical Care Medicine, Department of Medicine, and.
Grace C BinghamDepartment of Biomedical Engineering, School of Medicine, University of Virginia, Charlottesville, Virginia.ORCID 0000-0002-5223-0460
Christopher F PastoreDivision of Pulmonary and Critical Care Medicine, Department of Medicine, and.ORCID 0000-0002-1002-6138
Catherine A BonhamDivision of Pulmonary and Critical Care Medicine, Department of Medicine, and.ORCID 0000-0001-9132-4083
Marcus R ClarkSection of Rheumatology, Department of Medicine, University of Chicago, Chicago, Illinois.ORCID 0000-0003-4747-0387
Nathan R SchoettlerSection of Pulmonary and Critical Care Medicine, Department of Medicine, and.ORCID 0000-0001-9851-6352
Mary E StrekSection of Pulmonary and Critical Care Medicine, Department of Medicine, and.ORCID 0000-0002-7671-1023
Robert D GuzyDepartment of Medicine, University of Wisconsin at Madison, Madison, Wisconsin.ORCID 0000-0001-8420-6177
Ayodeji AdegunsoyeSection of Pulmonary and Critical Care Medicine, Department of Medicine, and.ORCID 0000-0002-7015-9610
Imre NothDivision of Pulmonary and Critical Care Medicine, Department of Medicine, and.ORCID 0000-0001-9846-5030
Paul J WoltersDepartment of Medicine, University of California, San Francisco, San Francisco, California.ORCID 0000-0002-3108-6164
Thomas H BarkerDepartment of Biomedical Engineering, School of Medicine, University of Virginia, Charlottesville, Virginia.ORCID 0000-0002-3218-8111
Mark S AndersonDepartment of Medicine, University of California, San Francisco, San Francisco, California.ORCID 0000-0002-3093-4758
Joseph L DeRisiUniversity of California, San Francisco and Chan Zuckerberg Biohub, San Francisco, California; and.ORCID 0000-0002-4611-9205
Anthony K ShumDepartment of Medicine, University of California, San Francisco, San Francisco, California.ORCID 0000-0001-5139-4802
Anne I SperlingDivision of Pulmonary and Critical Care Medicine, Department of Medicine, and.ORCID 0000-0002-4265-9212

Funding

Vaccines and Therapies Against BotulismU54AI057153 · NIAID · UNIVERSITY OF CHICAGO · PI SHUMAN, HOWARD A · 2003 to 2013
$87.6M
RESEARCH TRAINING IN RESPIRATORY BIOLOGYT32HL007605 · NHLBI · UNIVERSITY OF CHICAGO · PI Yun Fang, Gokhan M. Mutlu · 1985 to 2026
$18.1M
INFECTIOUS DISEASES TRAINING PROGRAMT32AI007046 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Alison K Criss, William A Petri · 1985 to 2026
$15.3M
INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007090 · NIAID · UNIVERSITY OF CHICAGO · PI Peter Aidan Savage · 1985 to 2026
$11.7M
1/2 Prospective tReatment EffiCacy in IPF uSlng genOtype for Nac Selection (PRECISIONS) trial and Molecular Endophenotyping in Idiopathic Pulmonary Fibrosis and Interstitial Lung Diseases studyUH3HL145266 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI MARTINEZ, FERNANDO J, NOTH, IMRE · 2021 to 2025
$11.6M
Project-003U19AI162310 · NIAID · UNIVERSITY OF CHICAGO · PI Marcelo A. Nobrega, Carole Ober · 2021 to 2026
$10.6M
INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007496 · NIAID · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Michael G. Brown, Coleen A McNamara · 1995 to 2026
$10.2M
University of Chicago Autoimmunity Center of ExcellenceU19AI082724 · NIAID · UNIVERSITY OF CHICAGO · PI WILSON, PATRICK CHRISTOPHER · 2009 to 2023
$7.2M
Unraveling the molecular mechanisms of impaired central tolerance in COPA syndromeR01AI168299 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Anthony Shum · 2022 to 2026
$3.3M
Architectural structure and regulation of TOLLIP in IPFR01HL130796 · NHLBI · UNIVERSITY OF VIRGINIA · PI NOTH, IMRE · 2016 to 2019
$3.1M
The role of quantitative CT and radiomic biomarkers for precision medicine in pulmonary fibrosisR01HL171918 · NHLBI · UNIVERSITY OF VIRGINIA · PI Imre Noth · 2024 to 2026
$2.2M
Modeling to Design Treatments for Idiopathic Lung FibrosisR01HL155143 · NHLBI · UNIVERSITY OF VIRGINIA · PI BARKER, THOMAS HARRISON, PEIRCE-COTTLER, SHAYN · 2021 to 2024
$2.2M
American Heart AssociationNational Institute of Health R01 HL13079NCI NIH HHS F99 CA264411NHLBI NIH HHS 1R01HL155143NHLBI NIH HHS F31 HL156659NHLBI NIH HHS K08 HL153955NHLBI NIH HHS K08 HL165106NHLBI NIH HHS K08HL165106NHLBI NIH HHS K12 HL119995NHLBI NIH HHS K23 HL143135NHLBI NIH HHS K23 HL146942NHLBI NIH HHS L30 HL154452NHLBI NIH HHS R01 HL130796NHLBI NIH HHS R01 HL155143NHLBI NIH HHS R01 HL171918NHLBI NIH HHS T32 HL007605NHLBI NIH HHS UH3 HL145266NIAID NIH HHS R01 AI168299NIAID NIH HHS R01 AI68299NIAID NIH HHS R21 AI126031NIAID NIH HHS R21 AI149416NIAID NIH HHS T32 AI007046NIAID NIH HHS T32AI007046NIAID NIH HHS T32 AI007090NIAID NIH HHS T32 AI007496NIAID NIH HHS U19 AI082724NIAID NIH HHS U19 AI162310NIAID NIH HHS U54 AI057153Pulmonary Fibrosis FoundationThe Nina Ireland Program for Lung Health at UCSFThe UCSF Clinical Translational Sciences InstituteUniversity of Virginia Raven Fellowship
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adaptive ImmunityIdiopathic Pulmonary FibrosisLung Diseases, InterstitialLymph NodesAgedAutoantibodiesFemaleHumansLungMaleMiddle AgedAutoantibodiesadaptive immunitygerminal centersinterstitial lung diseaselymph nodespulmonary fibrosis

Identifiers

PMID40815686
PMCPMC12555057

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.