ArticleScience advances2025
ACSS2 coupled with KAT7 regulates histone β-hydroxybutyrylation to enhance transcription.
Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Histone Post-Translational Modifications Regulating Ferroptosis: The Molecular Mechanisms and Disease Associations.Cell biochemistry and function · 2026Review
- The impact of microbial metabolites on host chromatin and epigenetic regulation.Nature metabolism · 2026Review
- Advances in Lipid Metabolism Reprogramming in Hepatocellular Carcinoma.Journal of clinical and translational hepatology · 2026Review
- ACSS2-KAT5 complex-driven histone crotonylation orchestrates a pro-inflammatory program to promote the transition from MASLD to MASH.Nature communications · 2026Article
- β-Hydroxybutyrate Exposure is Associated with Increased THCellular and molecular neurobiology · 2026Article
- Monocarboxylate transporter 2 regulates maintenance of myelin and axonal integrity by oligodendrocytes.Nature communications · 2026Article
- Chemical biology tools for studying histone post-translational modifications.Cell chemical biology · 2026Review
- Coming to light: the transcriptional regulatory roles of histone lysine crotonylation in health and disease.Cellular & molecular biology letters · 2026Review
- β-Hydroxybutyrate Attenuates Diabetic Kidney Disease Partially Via β-hydroxybutyrylation of Nrf2.Inflammation · 2026Article
- β-Hydroxybutyrate upregulates hepatic histone β-hydroxybutyrylation modification, promotes the expression of PPARα, and alleviates the hepatic steatosis in MASLD.Clinical epigenetics · 2026Article
- Comprehensive Proteomics and β-Hydroxybutyrylation Profiling in Starvation-Induced Gastrocnemius Muscle Remodeling.Biology · 2026Article
- Ketogenic diet and Parkinson's disease.Frontiers in molecular neuroscience · 2026Review
- Ketone bodies in kidney diseases: novel insights.Frontiers in immunology · 2026Review
- From ketogenic metabolism to targeted therapeutics: current advances in β-hydroxybutyrylation.Frontiers in immunology · 2025Review
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Authors and funding
14 authors.
Funding
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Abstract
Histone lysine β-hydroxybutyrylation (Kbhb) is an epigenetic mark linking ketone metabolism to transcription. However, the molecular mechanism by which β-hydroxybutyrate is converted to β-hydroxybutyryl-coenzyme A (BHB-CoA), the cofactor for Kbhb, remains unknown. Here, we report that acetyl-CoA synthetase short-chain family member 2 (ACSS2) coupled with lysine acetyltransferase 7 (KAT7) modulates β-hydroxybutyrylation on lysine 9 of histone H3 (H3K9bhb) to promote transcription. We show that KAT7 serves as a β-hydroxybutyryltransferase and preferably catalyzes histone Kbhb, especially H3K9bhb, in 1171 identified Kbhb substrates. ACSS2 is a BHB-CoA synthetase. This enzyme can sense cellular β-hydroxybutyrate and translocate into the nucleus, where it binds to and colocalizes with KAT7 at specific locus of chromatin. The ACSS2-generated BHB-CoA can fuel KAT7 for histone H3K9bhb. We demonstrate that the β-hydroxybutyrate drives the ACSS2-KAT7-H3K9bhb axis to promote epigenetic regulation and tumor cell growth. Our study not only identifies the founding member of BHB-CoA ligase but also reveals the mechanism underlying KAT7-catalyzed histone Kbhb using ACSS2-generated BHB-CoA.
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