Evidence map›Paper›PMID 40815648›Full record

ArticleScience advances2025

Difluoroboronated tetrazine probes for rapid bioorthogonal fluorescence activation, no-wash STED imaging, and triggered drug release.

Xiaomei Zhu, Jie Zhang, Haoxing Geng, Kai Wang, Yue Li, Xiuxiu Yang, Heng Shi, Junjie Tai, Xueyuan Yan, Yunfang Yang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. In Situ Construction of Imidazopyridinium Fluorescent Labels for Bioconjugation.Angewandte Chemie (International ed. in English) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaomei ZhuZhejiang Key Laboratory of Functional Structural Lipid Synthesis and Application, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China.ORCID 0009-0006-7315-6278
Jie ZhangDepartment of Chemistry and COSDAF (Centre of Super-Diamond and Advanced Films), City University of Hong Kong, Hong Kong 999077, China.ORCID 0000-0003-4335-3546
Haoxing GengZhejiang Key Laboratory of Functional Structural Lipid Synthesis and Application, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China.
Kai WangZhejiang Key Laboratory of Functional Structural Lipid Synthesis and Application, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China.
Yue LiZhejiang Key Laboratory of Functional Structural Lipid Synthesis and Application, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China.
Xiuxiu YangZhejiang Key Laboratory of Functional Structural Lipid Synthesis and Application, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China.
Heng ShiDepartment of Chemistry and COSDAF (Centre of Super-Diamond and Advanced Films), City University of Hong Kong, Hong Kong 999077, China.ORCID 0000-0002-8695-7449
Junjie TaiCollege of Chemical Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China.
Xueyuan YanCollege of Chemical Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China.ORCID 0009-0007-7154-8902
Yunfang YangCollege of Chemical Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China.ORCID 0000-0002-6287-1640
Hongyan SunDepartment of Chemistry and COSDAF (Centre of Super-Diamond and Advanced Films), City University of Hong Kong, Hong Kong 999077, China.ORCID 0000-0003-0932-6405
Qing ZhuZhejiang Key Laboratory of Functional Structural Lipid Synthesis and Application, College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310014, China.ORCID 0000-0002-0761-9434

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A unique class of bioorthogonal fluorogenic probes, based on difluoroboronated tetrazine (

Indexed as

Drug LiberationFluorescent DyesOptical ImagingDoxorubicinFluorescenceHumansMicroscopy, FluorescenceDoxorubicinFluorescent Dyes

Identifiers

PMID40815648
PMCPMC12356250

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.