ArticleUnited European gastroenterology journal2025
Incidence and Long-Term Outcomes of Pouchitis in Ulcerative Colitis Patients.
Article in United European gastroenterology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Risk factors for chronic pouchitis in patients with ulcerative colitis following ileal pouch-anal anastomosis: a meta-analysis.Frontiers in medicine · 2026Pooled it
- Incidence and Long-Term Outcomes of Pouchitis in Ulcerative Colitis Patients.United European gastroenterology journal · 2025Article
- 'Call for More Biopsies During Pouchoscopy in Ulcerative Colitis'.United European gastroenterology journal · 2025Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIleal pouch-anal anastomosis (IPAA) is the preferred intervention for ulcerative colitis (UC) patients whose medical treatment fails. Acute severe ulcerative colitis (ASUC) can precipitate the need for urgent surgery, potentially influencing post-IPAA outcomes.
objectiveThis study details the incidence, disease course, and treatment of pouchitis and pouch failure in a population-based cohort of UC patients following IPAA construction.
methodsWe included all UC patients who underwent IPAA construction within two administrative regions in Denmark between November 1993 and April 2021 in a population-based cohort. Data spanning from diagnosis to January 2023 were manually extracted from electronic patient records and analyzed.
resultsAmong 233 patients, 118 (50.6%) experienced 519 pouchitis events. 437 (84.2%) had intermittent pouchitis, 60 (11.6%) had chronic antibiotic-dependent pouchitis, and 22 (4.2%) had chronic antibiotic-refractory pouchitis. There was no significant difference in the incidence of pouchitis between patients who underwent urgent surgery due to ASUC and those who underwent non-urgent surgery. Antibiotics were used in 89.6% of cases, with ciprofloxacin and metronidazole being the most common treatment. Thirty-two (13.7%) patients experienced 36 pouch failures, 6.9% experienced permanent pouch failure, with 8.3% of failures attributed to pouchitis.
conclusionHalf of the patients with IPAA experienced at least one episode of pouchitis. ASUC did not appear to increase the risk of pouchitis. The overall incidence of pouch failure was low, with pouchitis contributing to a minority of failures.
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