ArticleInfectious diseases and therapy2025
A Cost-Effectiveness Analysis of the Switch to 20-Valent Pneumococcal Conjugate Vaccine from Lower-Valent Pneumococcal Conjugate Vaccines in the French Pediatric Population.
Article in Infectious diseases and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- A Multi-Country Comparison of Number Needed to Vaccinate for PCV20 and PCV15 in Infants.Vaccines · 2026Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe pneumococcal conjugate vaccine (PCV) with valency of 20 (PCV20) was approved for pediatric use by the European Commission in 2024. However, PCV20 is not yet implemented into the French infant National Immunization Program (NIP). In this cost-effectiveness analysis, we compared PCV20 under a 3 + 1 schedule to the current standard of care (13-valent PCV [PCV13]) or 15-valent PCV (PCV15), both under a 2 + 1 schedule, for infant vaccination in France.
methodsThe study adopted a multiple-cohort population-level model under the French Collective perspective over a 10-year time horizon. Inputs were sourced from published and unpublished studies conducted in the French population, where available. Clinical outcomes included disease cases (i.e., invasive pneumococcal disease [IPD], inpatient pneumonia, and otitis media [OM]) and deaths. Incremental cost-effectiveness ratios were calculated on the basis of estimated costs and quality-adjusted life years (QALY) for PCV20 3 + 1 versus PCV15 2 + 1 and PCV13 2 + 1 in separate pairwise comparisons.
resultsCompared with PCV13 2 + 1 and PCV15 2 + 1, PCV20 3 + 1 was estimated to be dominant, resulting in improved public health and economic outcomes. PCV20 was predicted to prevent more disease cases versus PCV13 (IPD: 13,510; hospitalized pneumonia: 317,136; hospitalized OM: 66,579) and PCV15 (IPD: 11,187; hospitalized pneumonia: 255,790; hospitalized OM: 53,733) and provide cost-savings of €1,567,052,379 and €1,134,653,266 versus PCV13 and PCV15, respectively.
conclusionsThis study predicted that infant immunization with PCV20 was the most cost-effective option compared with PCV13 and PCV15. These results could help decision-makers implement the optimal PCV strategy in the French pediatric NIP.
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