Evidence map›Paper›PMID 40815461›Full record

ArticleMolecular biotechnology2026

GALNT18-Mediated O-Glycosylation Promotes Development of Nonalcoholic Steatohepatitis-Associated Hepatocellular Carcinoma Through Activation of EGR1/TGF-β1/Smad Signaling.

Dan Chen, Ying Nie, Li Shi, Dingfu Zhong, Jiajia Wu, Bei Jin, Dong Liu

Abstract read
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In one paragraph

Article in Molecular biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dan ChenDepartment of Gastroenterology, Jinhua People's Hospital, Jinhua, 321000, Zhejiang Province, People's Republic of China.
Ying NieDepartment of Gastroenterology, Jinhua People's Hospital, Jinhua, 321000, Zhejiang Province, People's Republic of China.
Li ShiDepartment of Gastroenterology, Jinhua People's Hospital, Jinhua, 321000, Zhejiang Province, People's Republic of China.
Dingfu ZhongDepartment of Gastroenterology, Jinhua People's Hospital, Jinhua, 321000, Zhejiang Province, People's Republic of China.
Jiajia WuDepartment of Gastroenterology, Jinhua People's Hospital, Jinhua, 321000, Zhejiang Province, People's Republic of China.
Bei JinDepartment of Gastroenterology, Jinhua People's Hospital, Jinhua, 321000, Zhejiang Province, People's Republic of China.
Dong LiuDepartment of Hepatobiliary Pancreatic Gastrointestinal Surgery, Jinhua People's Hospital, No.118, Dan Guang West Road, Xinshi Street, Jindong District, Jinhua, 321000, Zhejiang Province, People's Republic of China. li375dong@163.com.ORCID http://orcid.org/0000-0002-7890-8209

Funding

Application of Public Welfare Technology by Jinhua Science and Technology Bureau: Mechanism Study of Starch like Precursor Protein Promoting the Occurrence and Development of NASH Associated Liver Cancer No. 2022-4-145
6 · The paper itself

Abstract

Nonalcoholic steatohepatitis-associated hepatocellular carcinoma (NASH-HCC) is an increasing global health issue. Research indicates that amyloid precursor protein (APP) might be a diagnostic marker and therapeutic target for HCC. However, the specific role of O-glycosylation of APP in NASH-HCC remains unclear. A NASH-HCC mice model was established by feeding BALB/c inbred mice with a high-fat/high-cholesterol (HFHC) diet and injection of CCl

Indexed as

Carcinoma, HepatocellularEarly Growth Response Protein 1Liver NeoplasmsN-AcetylgalactosaminyltransferasesNon-alcoholic Fatty Liver DiseaseTransforming Growth Factor beta1Amyloid beta-Protein PrecursorAnimalsCell Line, TumorCell ProliferationDisease Models, AnimalGlycosylationHumansMaleMiceMice, Inbred BALB CAmyloid beta-Protein PrecursorEarly Growth Response Protein 1N-AcetylgalactosaminyltransferasesPolypeptide N-acetylgalactosaminyltransferaseSmad ProteinsTransforming Growth Factor beta1Amyloid precursor proteinEGR1/TGF-β1/Smad signaling pathwayNonalcoholic steatohepatitis-associated hepatocellular carcinomaO-glycosylation

Identifiers

PMID40815461

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.