SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025
Factors influencing adherence to oral nutritional supplementation in patients with gastrointestinal neoplasms: a mixed methods systematic review.
Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- The impact of potential food allergen exposure on wound healing after malignant tumor surgery: immune tolerance alterations and clinical risk assessment.Frontiers in immunology · 2026Review
- Health beliefs and quality of life in patients with gastric cancer: the chain mediating role of nutritional behaviors and nutritional status.Frontiers in oncology · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
objectiveTo explore specific determinants influencing oral nutritional supplementation (ONS) adherence in gastrointestinal neoplasm patients.
methodsThis PROSPERO-registered (CRD42024611358) systematic review followed PRISMA 2020 guidelines. Databases including PubMed, Web of Science, and CNKI were searched from inception to April 2025. Included studies underwent quality appraisal and integrative analysis using JBI mixed-methods guidelines.
resultsA total of 14 original studies were included, comprising 9 quantitative studies, 2 qualitative studies, and 3 mixed-methods studies, involving 1874 gastrointestinal neoplasm patients (1779 in quantitative studies and 95 in qualitative studies). Among the 9 quantitative studies, 1 was a discrete choice experiment. Through analysis, 29 influencing factors were identified, such as perceived benefits, educational level, family caregiver support, economic status, healthcare providers, palatability, adverse reactions, side effects of cancer treatments, and tumor types. These factors were categorized into 9 categories and mapped to the five dimensions of adherence proposed by the World Health Organization. Using a systematic prioritization framework (based on evidence strength, frequency of identification in original studies, and clinical intervenability), three critical determinants emerged as the most impactful: adverse reactions (confirmed by 10 original studies, including 6 high-quality studies), side effects of cancer treatments (supported by 7 original studies, with 5 high-quality studies), and perceived benefits (recognized by 6 original studies, including 5 high-quality studies).
conclusionsONS adherence is affected by multiple specific factors, with adverse reactions, cancer treatment side effects, and perceived benefits as critical priorities. Interventions should include symptom management for adverse reactions, supportive care for treatment side effects, standardized nutrition education to enhance perceived benefits, and personalized adjustments for palatability. These recommendations guide targeted clinical interventions and future research on improving ONS adherence.
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