Trial reportEndocrine2025
Repurposing nitazoxanide in type 2 diabetes mellitus: a randomized controlled trial.
Trial report in Endocrine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06010992 (A Clinical Study Evaluating the Potential Benefit of Nitazoxanide in Patients With Type 2 Diabetes Mellitus), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Clinical Study Evaluating the Potential Benefit of Nitazoxanide in Patients With Type 2 Diabetes Mellitus
Who cites it
1 citing paper in PubMed.
- DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy.MedComm · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePreclinical data suggest nitazoxanide (NTZ) as a potential PPAR-γ agonist with potential benefits in type 2 diabetes. This pilot trial aimed to explore the tolerability and preliminary effects of NTZ as an add-on therapy to the existing metformin-vildagliptin combination on glycemic control and inflammatory biomarkers in type 2 diabetes patients.
methodsEighty-eight patients were analyzed in the control and NTZ groups (44 per group). All patients were treated with metformin-vildagliptin combination. The NTZ group received 500 mg nitazoxanide orally twice daily. The primary outcome was glycemic control, assessed by glycated hemoglobin (HbA1c) and fasting blood glucose. Secondary outcomes included fasting insulin, serum interleukin-6 (IL-6), high mobility group box 1 (HMGB-1), asprosin, and malondialdehyde (MDA). All outcomes were measured at baseline and after three months.
resultsA between-groups comparison revealed significantly lower inflammatory markers with NTZ compared to control [IL-6: 23.64 ng/L (21.00-32.71) vs. 32.52 ng/L (29.63-36.13) and HMGB-1: 10.46 ng/mL (6.37-14.61) vs. 22.60 ng/mL (20.18-27.37), P < 0.001 for both]. HbA1c, fasting blood glucose, insulin, asprosin, and MDA were not considerably different between the two groups. Markedly lower levels of IL-6 (P = 0.009), HMGB-1 (P < 0.001), asprosin, (P = 0.002), and MDA (P < 0.001) were observed following NTZ treatment. Conversely, IL-6 and HMGB-1 increased significantly in the control group (P < 0.001 for both). Other biomarkers did not change significantly in both groups.
conclusionNTZ may alleviate oxidative stress and inflammation in type 2 diabetes despite no improvement in glycemic parameters.
trial registrationThis trial is registered on ClinicalTrials.gov under the name: Nitazoxanide as Adjuvant Therapy in Type 2 Diabetes Mellitus with the identifier: NCT06010992. Registration date: 8-2023.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.