Evidence map›Paper›PMID 40815377›Full record

SynthesisPediatric radiology2025

A systematic review of radiation dose to the eye lens from pediatric brain computed tomography scans.

Amanda Alison Perdomo, Jake Cameron Forster, Mohamed Khaldoun Badawy

Abstract readSystematic Review
In one paragraph

Synthesis in Pediatric radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Amanda Alison PerdomoRoyal Childrens Hospital Melbourne, 50 Flemington Road, Parkville, VIC, 3052, Australia. amanda.perdomo@rch.org.au.
Jake Cameron ForsterUniversity of Adelaide, Adelaide, Australia.
Mohamed Khaldoun BadawyMonash Health, Melbourne, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWith the increasing use of pediatric brain computed tomography (CT) and the International Commission on Radiological Protection's revised threshold for radiation-induced lens opacities, concerns have grown regarding cumulative radiation exposure to the eye lens.

objectiveThis review examines the magnitude of lens doses reported in pediatric brain CT and the methodologies used to estimate these doses.

methodsA systematic literature search of MedLine, Embase, and PubMed (2012-2024) identified 18 eligible studies, including direct patient measurements, phantom-based experiments, and computational modeling.

resultsReported lens doses varied widely across studies. Software-based tools generally estimate higher doses than those measured directly on patients or phantoms. Multiple dose-reduction strategies such as gantry tilting, organ-based tube current modulation, and protocol optimization were effective in significantly lowering lens exposure without compromising diagnostic quality.

conclusionIn all cases, individual scan doses remain below the cataractogenic threshold. However, children undergoing repeated imaging may exceed this limit over time. Cumulative lens dose tracking and routine implementation of orbit-sparing techniques are recommended to reduce long-term radiation risk in vulnerable pediatric populations.

Indexed as

BrainLens, CrystallineRadiation DosageTomography, X-Ray ComputedChildHumansPhantoms, ImagingRadiation ProtectionCataractComputed tomographyEye lensPediatricsRadiation doseSystematic review

Identifiers

PMID40815377
PMCPMC12602571

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.