Evidence map›Paper›PMID 40815366›Full record

ArticleProbiotics and antimicrobial proteins2026

Alginate Oligosaccharide Alleviates Salmonella Typhimurium-Induced Liver Injury by Regulating Oxidative Stress, Apoptosis, and Inflammatory Signaling Pathway.

Yanan Liu, Xinyu Zhang, Yao Ge, Haozhen Liu, Yinfeng Chen, Yang Yang, Ying Yang, Zhenlong Wu

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Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yanan LiuState Key Laboratory of Animal Nutrition and Feeding, Department of Companion Animal Science, China Agricultural University, Beijing, 100193, People's Republic of China.
Xinyu ZhangState Key Laboratory of Animal Nutrition and Feeding, Department of Companion Animal Science, China Agricultural University, Beijing, 100193, People's Republic of China.
Yao GeBeijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing, 100193, People's Republic of China.
Haozhen LiuState Key Laboratory of Animal Nutrition and Feeding, Department of Companion Animal Science, China Agricultural University, Beijing, 100193, People's Republic of China.
Yinfeng ChenState Key Laboratory of Animal Nutrition and Feeding, Department of Companion Animal Science, China Agricultural University, Beijing, 100193, People's Republic of China.
Yang YangState Key Laboratory of Animal Nutrition and Feeding, Department of Companion Animal Science, China Agricultural University, Beijing, 100193, People's Republic of China.
Ying YangState Key Laboratory of Animal Nutrition and Feeding, Department of Companion Animal Science, China Agricultural University, Beijing, 100193, People's Republic of China.
Zhenlong WuState Key Laboratory of Animal Nutrition and Feeding, Department of Companion Animal Science, China Agricultural University, Beijing, 100193, People's Republic of China. wuzhenlong@cau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alginate oligosaccharide (AOS) is a kind of functional oligosaccharides obtained from the degradation of alginate, which has functional properties such as anti-inflammatory, antibacterial, and antioxidant activity. The aim of this study was to investigate whether AOS could alleviate Salmonella enterica serovar Typhimurium (S. Typhimurium)-induced liver injury. In our study, we found that AOS could alleviate S. Typhimurium-caused weight loss, enlargement of the liver and spleen in mice. In addition, AOS attenuated S. Typhimurium-induced inflammatory response as evidenced by the reduced ratio of AST/ALT, and lower the mRNA levels of Il-6, Il-1β, Tnf-α, Ccl3, and Ccl8. Moreover, AOS reduced H

Indexed as

AlginatesOligosaccharidesOxidative StressSalmonella typhimuriumAnimalsApoptosisLiverMaleMiceSignal TransductionAlginatesOligosaccharidesAlginate oligosaccharideApoptosisGut microbiotaInflammationOxidative stressSalmonella Typhimurium

Identifiers

PMID40815366

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.