Evidence map›Paper›PMID 40815339›Full record

ArticleAnnals of nuclear medicine2025

Diagnostic value of

Huan Ma, Chuangui Li, Qian Zhang, Jiayue Liu, Wei Zhao, Xiaoyi Guo, Nina Zhou, Daxi Xue

Abstract read
PubMed Publisher
In one paragraph

Article in Annals of nuclear medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Huan Ma *Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, 100142, China.
Chuangui Li *Department of Nuclear Medicine, First Affiliated Hospital of Hebei North University, Zhangjiakou, 075000, China.
Qian ZhangKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, 100142, China.
Jiayue LiuKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, 100142, China.
Wei ZhaoKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, 100142, China.
Xiaoyi GuoKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, 100142, China. 15833916752@163.com.
Nina ZhouKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing, 100142, China. 13681011804@163.com.
Daxi XueDepartment of Ophthalmology, Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated People's Hospital Northwest University, Xi'an, 710004, China. newxuedaxi@163.com.ORCID http://orcid.org/0009-0008-1702-1170

Funding

Clinical Medicine Excellent Talent Training Program of Hebei Province ZF2024223Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences and Peking Union Medical College BJCH2024CZ02
6 · The paper itself

Abstract

objectiveTo evaluate the diagnostic performance of

methodsThis retrospective study enrolled 67 patients with histopathologically confirmed CM who underwent

resultsA total of 16 patients were confirmed metastasis. The median interval from surgery to metastasis was 20.3 months (range 1-100 months), with 56.3% (9/16) occurring within the first postoperative year. PET/CT detected metastases in 13 patients, missed metastases in 3 patients (2 with small preauricular lymph nodes and 1 with tiny pulmonary metastases), and misdiagnosed 1 patient with parotid benign nodules as metastatic. PET/CT demonstrated a sensitivity of 81.3%, specificity of 98.0%, and accuracy of 94.0%. The most common metastatic sites included lymph nodes (62.5%), bone (37.5%), lung (31.3%), and liver (25.0%), with PET/CT demonstrating detection rates of 95.5%, 100%, 86.7%, and 100%, respectively. PET/CT also identified metastases in rare sites, including the thyroid, cerebellum, adrenal glands, pericardium, pancreas, and subcutaneous/soft tissue. Lymph node metastases in CM predominately occurred in ipsilateral regional nodes (90.1%), with rare bilateral involvement (9.1%). Metastatic lymph nodes in the cervical and submandibular regions showed significantly higher mean SUVmax (11.6 ± 10.5 vs. 2.9 ± 0.9; p = 0.005) and T/NT ratios (6.9 ± 8.2 vs. 3.0 ± 1.0; p = 0.011) compared to inflammatory lymph nodes. SUVmax of metastatic lymph nodes, lung metastases, and liver metastases showed positive correlations with lesion size (p < 0.05 for all). Among metastatic lymph nodes, 53.2% had a short-axis diameter < 10 mm, and 59.1% of bone metastases exhibited no abnormal CT density.

conclusion

Indexed as

Conjunctival NeoplasmsFluorodeoxyglucose F18MelanomaPositron Emission Tomography Computed TomographyAdultAgedAged, 80 and overFemaleFollow-Up StudiesHumansMaleMiddle AgedNeoplasm MetastasisRetrospective StudiesYoung AdultFluorodeoxyglucose F1818F-FDGConjunctival melanomaLymph nodeMetastasesPET/CTSUVmax

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.