ArticleEuropean radiology2026
Significant dose reduction employing dual-low-dose PET/CT in pediatric lymphoma: maintaining diagnostic, staging, and response-assessing efficacy.
Article in European radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo evaluate the clinical efficacy of a dual-low-dose total-body PET/CT protocol in pediatric lymphoma patients, incorporating low-dose PET imaging in combination with two distinct low-dose CT acquisition strategies. MATERIALS AND
methodsPediatric lymphoma patients (≤ 18 years) receiving half-dose [
resultsA total of 246 pediatric patients were enrolled (9.2 ± 3.8 years, 180 male). The LDCT (n = 127) and ULDCT (n = 119) had similar clinical characteristics (p > 0.05) except for male percentage (78.7% vs. 67.2%, p = 0.042). The total ED of ULDCT was significantly lower than that of LDCT (5.6 ± 1.9 mSv vs. 9.7 ± 3.2 mSv, p < 0.001). Both groups showed acceptable subject image quality and were comparable in main objective parameters. ULDCT showed a sensitivity lower than LDCT (99.0% vs. 99.9%, p = 0.010) in diagnosing lymph node lesions, while their specificity (96.0% vs. 94.3%) and area under curve (AUC, 0.978 vs. 0.982) were similar (both p > 0.05). LDCT and ULDCT were also comparable in diagnosing extranodal involvements (AUCs > 0.800), staging accuracy (94.6% and 93.6%), and response assessment accuracy (97.6% and 96.3%).
conclusionsDual-low-dose total-body PET/CT allowed a significant reduction in total ED without compromising imaging quality and diagnosis performance in pediatric lymphoma patients. KEY POINTS: Question [
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