Evidence map›Paper›PMID 40815290›Full record

ArticleEuropean journal of psychotraumatology2025

RESET post-traumatic stress disorder: clinical protocol integrating reconsolidation, exposure, short-term emotional transformation.

Dori Rubinstein, Maayan Abargil, Or Duek, Ilan Harpaz-Rotem

Abstract read
In one paragraph

Article in European journal of psychotraumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dori RubinsteinDepartment of Psychiatry, Harpaz-Rotem PTSD Treatment & Research Lab, Yale University School of Medicine, New Haven, CT, USA.
Maayan AbargilDepartment of Psychiatry, Harpaz-Rotem PTSD Treatment & Research Lab, Yale University School of Medicine, New Haven, CT, USA.
Or DuekDepartment of Psychiatry, Harpaz-Rotem PTSD Treatment & Research Lab, Yale University School of Medicine, New Haven, CT, USA.
Ilan Harpaz-RotemDepartment of Psychiatry, Harpaz-Rotem PTSD Treatment & Research Lab, Yale University School of Medicine, New Haven, CT, USA.

Funding

Using Ketamine to enhance memory reconsolidation and extinction of overgeneralized fear in individuals diagnosed with PTSDR61MH129559 · NIMH · YALE UNIVERSITY · PI HARPAZ-ROTEM, ILAN · 2023 to 2024
$2.4M
NIMH NIH HHS R61 MH129559
6 · The paper itself

Abstract

backgroundThe RESET (Reconsolidation, Exposure, and Short-term Emotional Transformation) clinical protocol is an intensive, structured trauma-focused intervention designed to treat post-traumatic stress disorder (PTSD) within six daily sessions. While Prolonged Exposure (PE) therapy remains a leading evidence-based treatment, challenges such as high dropout rates and relapses highlight the need for innovative approaches.

objectiveThis paper outlines RESET's theoretical foundations, session structure, and clinical implementation, offering a detailed framework for its integration into psychotrauma practice.

methodRESET integrates principles of memory reconsolidation, exposure therapy, and psychodynamic case formulation to facilitate the rapid processing and integration of traumatic memories. The protocol includes psychoeducation, targeted exposure, dynamic case formulation, and guided trauma processing, providing a comprehensive yet time-efficient intervention.

resultsBy leveraging memory reconsolidation mechanisms within an intensive treatment format, RESET has the potential to enhance therapeutic engagement, reduce dropout, optimize PTSD symptom reduction, and foster sustained emotional processing. Its structured design ensures feasibility and adherence while maintaining the efficacy of traditional PTSD treatments.

conclusionsOngoing clinical trials are evaluating RESET's effectiveness across diverse populations, positioning it as both a scalable stand-alone intervention and a valuable adjunct to long-term psychotherapies.

Indexed as

EmotionsImplosive TherapyMemory ConsolidationStress Disorders, Post-TraumaticClinical ProtocolsHumansexposición intensiva prolongada (iPE en su sigla en inglés)exposure therapyformulación psicodinámica de casosintensive prolonged exposure (iPE)memory reconsolidationPost-traumatic stress disorder (PTSD)psicoterapia del traumapsychodynamic case formulationreconsolidación de la memoriaterapia de exposiciónTrastorno de estrés postraumático (TEPT)trauma psychotherapy

Identifiers

PMID40815290
PMCPMC12360050

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.