ArticleJACC. Case reports2025
Incessant Electrical Storm in a Patient With Brugada Syndrome Provoked by Previously Unreported Syndrome-Inducing Medication.
Article in JACC. Case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundBrugada syndrome is a disorder associated with an increased risk of syncope, ventricular fibrillation, and sudden cardiac death in a structurally normal heart. The condition is related to mutations in cardiac cell transmembrane channels, but many cases do not have identifiable genetic mutations. Arrhythmic events are usually induced by specific triggers including a number of medications. Ventricular storm in Brugada syndrome is rare but when it occurs it can be life threatening. CASE SUMMARY: We present a case of a patient receiving 5-fleurouracil home infusion monotherapy who developed prolonged ventricular storm and was found to have previously undiagnosed Brugada syndrome. The patient was successfully treated with isoproterenol, quinidine, and arrhythmogenic trigger reduction and made a full recovery. DISCUSSION: 5-flourouracil has never previously been reported as a possible inducer of Brugada syndrome. Additionally, this is the most prolonged case of electrical storm in a patient with Brugada syndrome reported to date.
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