Evidence map›Paper›PMID 40815160›Full record

ArticlemSystems2025

Renal pelvis urobiome dysbiosis is associated with postoperative systemic inflammatory response syndrome after percutaneous nephrolithotomy.

Qing Wang, Xiaolong Chen, Guanyun Deng, Kunyuan Huang, Senyuan Hong, Kehua Jiang

Abstract read
In one paragraph

Article in mSystems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qing WangDepartment of Urology, Guizhou Provincial People's Hospital, Guiyang, Guizhou, China.ORCID 0000-0001-6540-1858
Xiaolong ChenDepartment of Urology, Guizhou Provincial People's Hospital, Guiyang, Guizhou, China.
Guanyun DengDepartment of Urology, Guizhou Provincial People's Hospital, Guiyang, Guizhou, China.
Kunyuan HuangDepartment of Urology, Guizhou Provincial People's Hospital, Guiyang, Guizhou, China.
Senyuan HongDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.ORCID 0000-0002-0466-0917
Kehua JiangDepartment of Urology, Guizhou Provincial People's Hospital, Guiyang, Guizhou, China.ORCID 0000-0002-9446-3158

Funding

Guizhou Provincial Science and Technology Project QKHJC-ZK[2022]YB258National Natural Science Foundation of China 82160147Subsidy funding for the 2021 National Natural Science Foundation of China GPPH-NSFC-2021-9
6 · The paper itself

Abstract

Early prediction and diagnosis of systemic inflammatory response syndrome (SIRS) following percutaneous nephrolithotomy (PCNL) are critical. This study aimed to investigate differences in clinical characteristics and the renal pelvis urobiome between patients with and without post-PCNL SIRS to identify potential predictive biomarkers. Patients undergoing unilateral PCNL were categorized into SIRS(+) and SIRS(-) groups based on postoperative SIRS status. Renal pelvis urine samples were collected for 2bRAD-M sequencing to profile the urobiome. Clinical data and urobiome composition were compared between the groups. Logistic regression identified preoperative serum albumin-globulin ratio (AGR) as an independent protective factor and operative time as an independent risk factor for post-PCNL SIRS, with an area under the receiver operating characteristic curve (AUC) of 0.76. Diversity analysis revealed distinctive microbial differences between the two groups. Through differential analysis and random forest, we screened six species, including

Indexed as

DysbiosisKidney PelvisNephrolithotomy, PercutaneousPostoperative ComplicationsSystemic Inflammatory Response SyndromeAdultAgedFemaleHumansMaleMiddle Aged2bRAD-Mpercutaneous nephrolithotomysystemic inflammatory response syndromeurobiome

Identifiers

PMID40815160
PMCPMC12455945

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.