SynthesisEuropean neurology2025
Alcohol Use and Types and Ischemic Stroke: A Systematic Review and Meta-Analysis.
Synthesis in European neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- From Serum to Genome: γ-Glutamyltransferase Gene Family Variants Shape Ischemic Stroke Risk via Sex-Specific Gene-Environment Interactions.Life (Basel, Switzerland) · 2026Article
- Association of long-term alcohol consumption with DSA-defined concurrent intracranial and extracranial steno-occlusive involvement in acute ischemic stroke.Frontiers in neurology · 2026Article
- Multifactorial stratified analysis of two novel metabolism-related indices for predicting stroke in mild cognitive impairment.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
introductionThis systematic review and meta-analysis was conducted to investigate the association between alcohol use pattern and ischemic stroke risk.
methodsWe searched PubMed, Scopus, Web of Sciences, Embase, and CENTRAL till the 1st of June, 2024. Studies were included if they were articles that assessed the impact of alcohol drinking pattern on the risk of ischemic stroke. The random-effect model was utilized to combine the results. Data analysis was performed using Meta XL, version 5.3.
resultsThe total number of included participants was 21,293,471 from 125 studies. The model that investigated the association between light alcohol use and ischemic stroke risk showed no association (relative risk [RR] = 0.97, 95% confidence interval [CI]: 0.89-1.05). Moderate alcohol use was associated with significant decrease in ischemic stroke risk (RR = 0.87; 95% CI: 0.83-0.92), while heavy alcohol use was associated with significant increase in ischemic stroke risk (RR = 1.31; 95% CI: 1.19-1.44). Subgroup analysis among males showed results similar to the primary analysis while among females, and only moderate alcohol drinking was significantly associated with ischemic stroke (RR = 0.50; 95% CI: 0.33-0.75). Moderate and heavy wine use was associated with significant reduction in ischemic stroke risk (RR = 0.61; 95% CI: 0.45-0.84; RR = 0.77; 95% CI: 0.63-0.93).
conclusionsOur analysis provided a strong and robust evidence that there was a significant association between moderate and heavy alcohol use with ischemic stroke risk. However, this association varied by several variables including type of alcohol with the effect being more protective among people who use wine.
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Registered trials
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