ArticleCornea2026
Long-Term Observations of the First Human Implantation of an Artificial Endothelial Layer for Endothelial Dysfunction: A Pilot Study.
Article in Cornea, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Outcomes of Synthetic Corneal Endothelial Implant in Patients with Corneal Oedema with or without Prior Endothelial Keratoplasty: A Case Series.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo describe the long-term observations of the first human implantation of EndoArt, a synthetic endothelial implant, in a small cohort of patients with corneal edema secondary to endothelial dysfunction.
methodsThis retrospective case series analyzed 5 eyes from 5 patients who underwent EndoArt implantation, with a minimum follow-up of 12 months. Clinical outcomes, including corrected distance visual acuity and central corneal thickness, were evaluated pre- and postoperatively. Rebubbling procedures and any complications were recorded. Histological analysis was performed on 1 explanted corneal button.
resultsThe mean follow-up was 38.4 ± 20 months (range: 19-72 months). A reduction in mean central corneal thickness was observed, from 741.2 ± 88.3 μm preoperatively to 558.4 ± 72.7 μm postoperatively ( P < 0.001). Corrected distance visual acuity improved in 4 of 5 eyes, although not significantly overall ( P = 0.19). The mean number of rebubbling procedures was 2.8 ± 1.3 per eye. No serious implant-related complications were observed during the follow-up period. Histological findings showed fibrocellular tissue partially integrating the implant, which may contribute to graft adherence. Two patients with Fuchs dystrophy received the device as a primary procedure because of ethical or religious constraints regarding donor tissue.
conclusionsThis small pilot series of the first human EndoArt implantation observed a significant reduction of corneal edema over time and a favorable safety profile in select patients. Although these findings are encouraging, they should be interpreted with caution given the limited sample size. Larger, controlled studies are needed to better understand the safety, efficacy, and long-term outcomes of this synthetic implant.
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