Evidence map›Paper›PMID 40815021›Full record

ArticleACS chemical neuroscience2025

Novel Copper Chelators Enhance Spatial Memory and Biochemical Outcomes in Alzheimer's Disease Model.

Mariana L M Camargo, Augusto B Farias, Giovana B Bertazzo, Rafael N Gomes, Kaio S Gomes, Lucas M Bosquetti, Silvia H Takada, Felipe C Braga, Caroline C Augusto, Bruno L Batista and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Heterotrimetallic Au@CuMaterials today. Bio · 2026
    Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mariana L M CamargoMetal Biochemistry and Oxidative Stress Laboratory, Center for Natural Sciences and Humanities, Federal University of ABC-UFABC, Santo André, São Paulo 09210-580, Brazil.
Augusto B FariasMetal Biochemistry and Oxidative Stress Laboratory, Center for Natural Sciences and Humanities, Federal University of ABC-UFABC, Santo André, São Paulo 09210-580, Brazil.
Giovana B BertazzoMetal Biochemistry and Oxidative Stress Laboratory, Center for Natural Sciences and Humanities, Federal University of ABC-UFABC, Santo André, São Paulo 09210-580, Brazil.
Rafael N GomesMetal Biochemistry and Oxidative Stress Laboratory, Center for Natural Sciences and Humanities, Federal University of ABC-UFABC, Santo André, São Paulo 09210-580, Brazil.
Kaio S GomesMetal Biochemistry and Oxidative Stress Laboratory, Center for Natural Sciences and Humanities, Federal University of ABC-UFABC, Santo André, São Paulo 09210-580, Brazil.
Lucas M BosquettiMetal Biochemistry and Oxidative Stress Laboratory, Center for Natural Sciences and Humanities, Federal University of ABC-UFABC, Santo André, São Paulo 09210-580, Brazil.
Silvia H TakadaLaboratory of Neurogenetics, Center for Mathematics, Computing and Cognition, Federal University of ABC-UFABC, São Bernardo do Campo, São Paulo 09606-045, Brazil.
Felipe C BragaDepartament of Chemistry, Federal University of São Carlos-UFSCar, São Carlos, São Paulo 13565-905, Brazil.
Caroline C AugustoMetal Biochemistry and Oxidative Stress Laboratory, Center for Natural Sciences and Humanities, Federal University of ABC-UFABC, Santo André, São Paulo 09210-580, Brazil.
Bruno L BatistaMetal Biochemistry and Oxidative Stress Laboratory, Center for Natural Sciences and Humanities, Federal University of ABC-UFABC, Santo André, São Paulo 09210-580, Brazil.
Kleber T de OliveiraDepartament of Chemistry, Federal University of São Carlos-UFSCar, São Carlos, São Paulo 13565-905, Brazil.ORCID 0000-0002-9131-4800
Giselle CerchiaroMetal Biochemistry and Oxidative Stress Laboratory, Center for Natural Sciences and Humanities, Federal University of ABC-UFABC, Santo André, São Paulo 09210-580, Brazil.ORCID 0000-0001-8606-5400

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study explores the potential of novel molecules that can act as copper chelators to treat Alzheimer's disease. Eight imines

Indexed as

Alzheimer DiseaseChelating AgentsCopperSpatial MemoryAmyloid beta-PeptidesAnimalsDisease Models, AnimalHippocampusHumansMaleMaze LearningRatsAmyloid beta-PeptidesChelating AgentsCopperAlzheimer’s diseasebioinorganic chemistrycoppercopper chelatorsdrug developmentiminemedicinal chemistryneurodegenerationneuroscienceoxidative stresspreclinical trialsquinoline

Identifiers

PMID40815021
PMCPMC12412111

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.