Trial reportActa orthopaedica2025
Early cup migration and wear as predictors for later aseptic loosening: a secondary evaluation of a randomized controlled RSA trial on cemented hip arthroplasties with 18-year follow-up.
Trial report in Acta orthopaedica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00698672 (A Prospective Randomized RSA-Study of Cemented Hip Prostheses With Five Different Articulations), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective Randomized RSA-Study of Cemented Hip Prostheses With Five Different Articulations
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0 citing papers in PubMed.
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThere is no clear evidence on whether migration or wear is the best predictor for later acetabular cup loosening. We aimed to investigate whether early wear or migration, measured via radiostereometric analysis (RSA), predicts later cup loosening. We also compared long-term aseptic loosening rates between conventional (CPE) and highly crosslinked polyethylene (XLPE) cups.
methodsData was drawn from a randomized controlled trial (RCT) (ClinicalTrials.Gov NCT00698672) of 150 patients receiving cemented total hip arthroplasties (THAs), with 10-year RSA follow-up. 5 groups were assessed based on implant combinations (Charnley or Spectron EF stems with CPE or XLPE cups and CoCr or Oxinium heads). Migration and wear up to 2 years were evaluated against 18-year cup survival using receiver operating characteristic (ROC) curves.
results19 cups (17 CPE, 2 XLPE) were loose at final follow-up. The area under the ROC curve (AUC) was 0.56 (95% confidence interval [CI] 0.40-0.73) for early migration and 0.85 (CI 0.77-0.94) for early polyethylene (PE) wear, with a difference of 0.29 (CI 0.09-0.49). Hazard ratio for loosening was 0.88 (CI 0.20-3.89) for early migration > 0.2 mm and 19.4 (CI 2.55-147) for early wear > 0.2 mm. At 18 years, survival free of aseptic loosening was 65% (CI 48-77) for CPE and 96% (CI 85-99) for XLPE cups, with a 9-fold higher risk of loosening for CPE.
conclusionEarly polyethylene wear, not migration, predicted long-term cup loosening. XLPE showed superior long-term performance over CPE with less wear, cup loosening, and revision.
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