ArticleeLife2025
Sub-type specific connectivity between CA3 pyramidal neurons may underlie their sequential activation during sharp waves.
Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Hippocampal CA3 connectomics reveals a gradient of mossy fiber inputs and selective feedforward inhibition onto pyramidal cells.Nature neuroscience · 2026Article
- Balancing Stability and Flow in Hippocampal Networks via Inductive Bias and Learned Symmetry Breaking.bioRxiv : the preprint server for biology · 2026Article
- Conditions for replay of neuronal assemblies.PLoS computational biology · 2026Article
- Optical Recordings of Unitary Synaptic Connections Reveal High and Random Local Connectivity between CA3 Pyramidal Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
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Authors and funding
10 authors.
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Abstract
The CA3 region of the hippocampus is the major site of sharp wave initiation, and a brain region crucially involved in learning and memory. Highly recurrent connectivity within its excitatory network is thought to underlie processes involved in memory formation. Recent work has indicated that distinct subpopulations of pyramidal neurons within this region may contribute differently to network activity, including sharp waves, in CA3. Exactly how these contributions may arise is not yet known. Here, we disentangle the local connectivity between two distinct CA3 cell types in mice: thorny and athorny pyramidal cells. We find an asymmetry in the connectivity between these two populations, with athorny cells receiving strong input from both athorny and thorny cells. Conversely, the thorny cell population receives very little input from the athorny population. Computational modeling suggests that this connectivity scheme may determine the sequential activation of these cell types during large network events such as sharp waves.
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