Evidence map›Paper›PMID 40814758›Full record

ArticleJournal of food science2025

Up-to-Date Research on the Composition of Blood Slaughterhouse By-Products Derived FBS Substitutes and Their Applicability to Animal Cell Culture.

Da Young Lee, Yeongwoo Choi, Dahee Han, Jinmo Park, Jin Soo Kim, Ermie Jr Mariano, Ji Won Park, Seok Namkung, Seung Yun Lee, Inho Choi and 2 more

Abstract read
In one paragraph

Article in Journal of food science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Da Young LeeDepartment of Animal Science and Technology, Chung-Ang University, Anseong-si, Gyeonggi-do, South Korea.
Yeongwoo ChoiDepartment of Animal Science and Technology, Chung-Ang University, Anseong-si, Gyeonggi-do, South Korea.
Dahee HanDepartment of Animal Science and Technology, Chung-Ang University, Anseong-si, Gyeonggi-do, South Korea.
Jinmo ParkDepartment of Animal Science and Technology, Chung-Ang University, Anseong-si, Gyeonggi-do, South Korea.
Jin Soo KimDepartment of Animal Science and Technology, Chung-Ang University, Anseong-si, Gyeonggi-do, South Korea.
Ermie Jr MarianoDepartment of Animal Science and Technology, Chung-Ang University, Anseong-si, Gyeonggi-do, South Korea.
Ji Won ParkDepartment of Animal Science and Technology, Chung-Ang University, Anseong-si, Gyeonggi-do, South Korea.
Seok NamkungDepartment of Animal Science and Technology, Chung-Ang University, Anseong-si, Gyeonggi-do, South Korea.
Seung Yun LeeDivision of Animal Science, Institute of Agriculture & Life Science, Gyeongsang National University, Jinju, Republic of Korea.
Inho ChoiDepartment of Medical Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, Republic of Korea.ORCID https://orcid.org/0000-0002-0884-5994
Seon-Tea JooDivision of Animal Science, Division of Applied Life Science (BK21 Four), Institute of Agriculture & Life Science, Gyeongsang National University, Jinju, Republic of Korea.
Sun Jin HurDepartment of Animal Science and Technology, Chung-Ang University, Anseong-si, Gyeonggi-do, South Korea.ORCID https://orcid.org/0000-0002-8861-6517

Funding

Chung-Ang UniversityNational Research Foundation of Korea
6 · The paper itself

Abstract

Fetal bovine serum (FBS) is a critical media component in cell culture, but it is also expensive and highly controversial from an animal welfare level, being of fetal blood origin. Therefore, our study aimed to develop FBS substitutes from slaughterhouse waste blood. We pooled the blood from slaughterhouse by-products (BSBPs) of three major livestock species (cattle, pigs, and chickens) and performed nutritional and hematological analyses of serum, plasma, whole blood, and cruor. Our substitutes were cultured with C2C12 cells, and the serum of each livestock species showed a cell proliferation effect. Nonetheless, the nutritional and hematological profiles of BSBPs from this study can provide basic component information for using livestock blood as a raw material for various preparations. Furthermore, the cell culture results using C2C12 cells indicate that using BSBPs can solve expensive cell culture costs and animal ethics issues by replacing FBS.

Indexed as

AbattoirsCell Culture TechniquesCulture MediaSerumWaste ProductsAnimalsCattleCell LineCell ProliferationChickensLivestockMiceSwineCulture MediaWaste Productsblood nutrientblood profileFBSslaughterhouse by‐product—blood

Identifiers

PMID40814758
PMCPMC12355341

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.