Evidence map›Paper›PMID 40814742›Full record

ReviewJournal of cosmetic dermatology2025

Sulfur and Its Derivatives in Dermatology: Insights Into Therapeutic Applications-A Narrative Review.

Yan Jing Chen, Jie Tang, Lin Wang, Wei Hua

Abstract readReview
In one paragraph

Review in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. The Latest Advances in Rosacea Treatment: A Systematic Review.Pharmaceuticals (Basel, Switzerland) · 2026
    Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yan Jing ChenDepartment of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0002-0259-5875
Jie TangCosmetics Safety and Efficacy Evaluation Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID https://orcid.org/0000-0001-9777-0535
Lin WangDepartment of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0001-8704-1136
Wei HuaDepartment of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu, China.ORCID https://orcid.org/0000-0002-3061-5749

Funding

The National Natural Science Foundation of China 82103767the Natural Science Foundation of Sichuan province 2023NSFSC1548
6 · The paper itself

Abstract

backgroundSulfur has been historically used in dermatological therapy due to its broad-spectrum antimicrobial and immunomodulatory activities and demonstrates therapeutic efficacy in conditions such as scabies, tinea versicolor, psoriasis, and atopic dermatitis. However, systematic analyses of the therapeutic potential and mechanisms of different forms of sulfur (e.g., sublimed and precipitated sulfur) and bioactive derivatives (e.g., hydrogen sulfide), particularly their effects on cutaneous diseases, remain underrepresented in contemporary literature.

aimOur study aimed to provide a comprehensive evaluation of pharmacological evidence and regulatory frameworks governing sulfur and its derivatives in dermatology, elucidating their mechanisms and therapeutic potential in various skin disorders.

methodsA comprehensive PubMed search was conducted using medical terms including sulfur, sulfide, hydrogen sulfide, and dermatology. Relevant literature published between 1947 and 2025 was reviewed.

resultsThis article not only summarizes the indications, potential therapeutic value, and mechanisms of sulfur and its derivatives in skin disorders, but also provides, for the first time, an overview of the usage restrictions and regulations established by food and drug administrations in most regions regarding the application of sulfur and its derivatives in dermatology.

conclusionsThis review highlights critical gaps in understanding the therapeutic bioactivity of sulfur and its derivatives, underscoring the need for preclinical studies to explore their translational potential as adjuvant therapies in dermatology.

Indexed as

Dermatologic AgentsSkin DiseasesSulfurDermatologyHumansHydrogen SulfideDermatologic AgentsHydrogen SulfideSulfurhydrogen sulfideselenium disulfidesulfur

Identifiers

PMID40814742
PMCPMC12355337

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.