Evidence map›Paper›PMID 40814642›Full record

ArticleKidney international reports2025

Prostaglandin Analogs and Eupatilin as Treatments for Nephronophthisis.

Alice Tata, Guillaume Rocha, Marguerite Hureaux, Alice S Serafin, Esther Porée, Lucie Menguy, Nicolas Goudin, Nicolas Cagnard, Lilian Gréau, Marc Fila and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alice TataLaboratory of Hereditary Kidney Disease, Imagine Institute, Université Paris Cité, INSERM UMR 1163, Paris, France.
Guillaume RochaLaboratory of Hereditary Kidney Disease, Imagine Institute, Université Paris Cité, INSERM UMR 1163, Paris, France.
Marguerite HureauxLaboratory of Hereditary Kidney Disease, Imagine Institute, Université Paris Cité, INSERM UMR 1163, Paris, France.
Alice S SerafinLaboratory of Hereditary Kidney Disease, Imagine Institute, Université Paris Cité, INSERM UMR 1163, Paris, France.
Esther PoréeLaboratory of Hereditary Kidney Disease, Imagine Institute, Université Paris Cité, INSERM UMR 1163, Paris, France.
Lucie MenguyLaboratory of Hereditary Kidney Disease, Imagine Institute, Université Paris Cité, INSERM UMR 1163, Paris, France.
Nicolas GoudinNecker Bio-image Analysis Platform, Structure Fédérative de Recherche Necker, INSERM US24, CNRS UMS3633, Paris, France.
Nicolas CagnardBioinformatic Platform, Institut Imagine-Structure Fédérative de Recherche Necker, INSERM U1163 and INSERM US24/CNRS UAR3633, Paris Cité University, Paris, France.
Lilian GréauGenomics Core Facility, Institut Imagine-Structure Fédérative de Recherche Necker, INSERM U1163 and INSERM US24/CNRS UAR3633, Paris Cité University, Paris, France.
Marc FilaDepartment of Pediatric Nephrology, CHU de Montpellier, Montpellier, France.
Luis Briseño-RoaMedetia Pharmaceuticals, Imagine Institute, Paris, France.
Jean-Philippe AnnereauMedetia Pharmaceuticals, Imagine Institute, Paris, France.
Sophie SaunierLaboratory of Hereditary Kidney Disease, Imagine Institute, Université Paris Cité, INSERM UMR 1163, Paris, France.
Alexandre BenmerahLaboratory of Hereditary Kidney Disease, Imagine Institute, Université Paris Cité, INSERM UMR 1163, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Primary cilia (PCs) are sensory antennae that are present on the majority of quiescent vertebrate cells where they mediate key signaling during development and in response to environmental stimuli. Defects in PCs result in a group of heterogeneous inherited disorders with overlapping phenotypes, called ciliopathies. Nephronophthisis is an autosomal recessive tubulointerstitial kidney ciliopathy with > 25 identified genes called Methods: Using a phenotypic screening approach in cultured cell lines, we previously identified prostaglandin analogues as candidate therapeutic molecules based on their ability to rescue ciliogenesis defects in kidney tubular cells from patients with Results: Eupatilin partially rescued Conclusion: Our study indicates that these molecules can show beneficial effects across genetic contexts and shed light on their potential as therapeutic interventions for nephronophthisis.

Indexed as

ciliopathiesEupatilinkidneynephronophthisisprimary ciliaprostaglandins

Identifiers

PMID40814642
PMCPMC12347849

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.