ArticleKidney international reports2025
Chronic Changes on Kidney Histology by a Multiclass Artificial Intelligence Model.
Article in Kidney international reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Artificial Intelligence in Kidney Transplant Pathology: Current Evidence, Limitations, and Relevance to the Banff Framework.Kidney international reports · 2026Review
- Rapid slide-level assessment of glomerular yield using virtual staining of unstained renal biopsy sections.Diagnostic pathology · 2026Article
- Can Artificial Intelligence Whole Slide Image-Based Methods Predict Kidney Function?Kidney international reports · 2025Article
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13 authors.
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Abstract
Introduction: Chronic changes in kidney histology are often approximated by using human vision but with limited accuracy. Methods: An interactive annotation tool trained an artificial intelligence (AI) model for segmenting structures on whole slide images (WSIs) of kidney tissue. A total of 20,509 annotations trained the AI model with 20 classes of structures, including separate detection of cortex from medulla. We compared the AI model detections with human-based annotations in an independent validation set. The AI model was then applied to 1426 donors and 1699 patients with renal tumor to calculate chronic changes as defined by measures of nephron size (glomerular volume, cortex volume per glomerulus, and mean tubular areas) and nephrosclerosis (globally sclerotic glomeruli, increased interstitium, increased tubular atrophy (TA), arteriolar hyalinosis (AH), and artery luminal stenosis from intimal thickening). We then assessed whether chronic kidney disease (CKD) outcomes were associated with these chronic changes. Results: During the AI model validation step, the agreement between the AI detections and human annotations was similar to the agreement between human pairs, except that the AI model showed less agreement with AH. Chronic changes calculated solely from AI-based detections associated with low glomerular filtration rate (GFR) during follow-up after kidney donation and with kidney failure after a radical nephrectomy for tumor. A chronicity score based on AI detections was calculated from cortex per glomerulus, percent glomerulosclerosis, TA foci density, and mean area of AH lesions and showed good prognostic discrimination for kidney failure (cross-validation C-statistic = 0.819). Conclusion: A multiclass AI model can help automate quantification of chronic changes on WSIs of kidney histology.
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