ArticleJPGN reports2025
Genital Crohn's disease in pediatrics and genetic associations.
Article in JPGN reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Recurrent Penile and Scrotal Edema as An Extracolonic Manifestation of Metastatic Crohn's Disease in an Adult Patient.ACG case reports journal · 2026Article
- Genital Crohn's disease in pediatrics and genetic associations.JPGN reports · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genital edema is a rare presentation of Crohn's disease (CD), also known as metastatic CD (MCD). This may precede, co-occur with, or follow gastrointestinal symptoms and present a diagnostic challenge. We aimed to characterize the features, clinical courses, pathogenesis, and outcomes of patients with MCD to increase understanding and promote timely management. A retrospective review of four patients diagnosed with MCD was conducted at Phoenix Children's and Children's Hospital Colorado. Patients presented with painful and painless penoscrotal swelling with and without erythema. Scrotal histopathology revealed granulomatous inflammation, and genetic testing identified pathogenic variants in NOD2, COL7A1, and Chek2, as well as additional variants of uncertain significance. Treatments included antibiotics, steroids, biologics, and methotrexate with mixed responses. Further research and clinical trials are needed to better understand the pathogenesis and develop best practices.
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Registered trials
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