ArticleJournal of family medicine and primary care2025
To study effects of metformin on thyroid functions in type-2 diabetes mellitus in patients attending OPD at Government Medical College, Bidar.
Article in Journal of family medicine and primary care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Metformin is one of the most used diabetes treating agents and has proved to be very effective, with a wide spectrum of efficacy, safety as well as being as agent that works at different spots in diabetes pathogenesis paradigm. Recently it has been reported that metformin is able to interfere with thyroid hormone profile, by decrease in the serum levels of thyrotropin (TSH) to subnormal levels in hypothyroid patients in stable levothyroxine (L-T4) treatment. Objectives: To study and compare the effect of metformin and non-metformin composed treatment of type-2 diabetes mellitus on thyroid functions. Methods: Comparative observational study was conducted among diabetic patients taking metformin as study and taking antidiabetic other than metformin as control group and analysed for the thyroid profile (TSH, fT3, fT4). Total 70 patients including both group from tertiary care teaching hospital were enrolled in to the study after taking informed verbal consent. Observations: The present study demonstrates that while the study group's fT3 and fT4 levels were lower than those of the control group, diabetic patients on non-metformin medication had statistically higher TSH (2.05 ± 0.15 mIU/mL vs. 2.35 ± 0.18 mIU/mL) levels than those taking metformin. Conclusion: Thyroid-stimulating hormone (TSH) levels may be somewhat or not at all decreased by metformin. Thyroid function monitoring is crucial for diabetic patients using metformin, particularly if they already have thyroid problems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.