Evidence map›Paper›PMID 40814415›Full record

ArticleCurrent opinion in behavioral sciences2025

Aligning brain and behavior.

Henry H Yin

Abstract read
In one paragraph

Article in Current opinion in behavioral sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Henry H YinDepartment of Psychology and Neuroscience, Department of Neurobiology, Duke University.

Funding

Neural Circuit Control of Postnatal Quiescent Neural Stem Cell ActivationR01MH105416 · NIMH · DUKE UNIVERSITY · PI YIN, HENRY · 2015 to 2024
$4.6M
The Role of Opponent Basal Ganglia Outputs in BehaviorR01NS094754 · NINDS · DUKE UNIVERSITY · PI Henry Yin · 2017 to 2026
$3.7M
Dissecting basal ganglia circuit mechanisms underlying instrumental learningR01DA040701 · NIDA · DUKE UNIVERSITY · PI Henry Yin · 2016 to 2026
$3.6M
The Role of Parafascicular Thalamic Circuits in Action GenerationR01NS121253 · NINDS · DUKE UNIVERSITY · PI YIN, HENRY · 2021 to 2025
$2.0M
NIDA NIH HHS R01 DA040701NIMH NIH HHS R01 MH105416NINDS NIH HHS R01 NS094754NINDS NIH HHS R01 NS121253
6 · The paper itself

Abstract

To understand how the brain generates behavior, both brain activity and behavior must be measured accurately. Although neuroscience has developed powerful tools for measuring brain activity, its behavioral measures are far more primitive, in part because it lacks a coherent conceptual framework for analyzing and interpreting behavior. Here I shall review key limitations in current studies of behavior, such as categorical measures and input/output analysis, which are manifested in conventional behavioral measures and experimental designs. I shall discuss how these limitations stem from the dominant linear causation paradigm which has impeded progress in understanding the relationship between neural activity and behavior. Finally, I shall review recent studies that use alternative strategies for studying how the brain generates behavior, and experimental results that challenge the linear causation paradigm. These results suggest hierarchical feedback control with intrinsic reference states, circular causation, and simultaneous reciprocal interactions between the organism and the environment.

Indexed as

basal gangliabehaviorControl theoryfeedbackrobotics

Identifiers

PMID40814415
PMCPMC12347085

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.