Evidence map›Paper›PMID 40814403›Full record

ReviewJournal of clinical orthopaedics and trauma2025

Incidence and risk factors of hip dislocation in children with cerebral palsy: A systematic review and pooled analysis.

Gabriele Giuca, Ilaria Sanzarello, Daniela Alessia Marletta, Salvatore Calaciura, Matteo Nanni, Danilo Leonetti

Abstract readReview
In one paragraph

Review in Journal of clinical orthopaedics and trauma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Dental Caries in Children and Youth With Cerebral Palsy: A Nationwide Study of Oral Health in Aotearoa New Zealand.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gabriele GiucaSection of Orthopaedics and Traumatology, Department of Biomedical Sciences and Morphological and Functional Images, University of Messina, 98122 Messina (ME) Italy.
Ilaria SanzarelloSection of Orthopaedics and Traumatology, Department of Biomedical Sciences and Morphological and Functional Images, University of Messina, 98122 Messina (ME) Italy.
Daniela Alessia MarlettaSection of Orthopaedics and Traumatology, Department of Biomedical Sciences and Morphological and Functional Images, University of Messina, 98122 Messina (ME) Italy.
Salvatore CalaciuraSection of Orthopaedics and Traumatology, Department of Biomedical Sciences and Morphological and Functional Images, University of Messina, 98122 Messina (ME) Italy.
Matteo NanniSection of Orthopaedics and Traumatology, Department of Biomedical Sciences and Morphological and Functional Images, University of Messina, 98122 Messina (ME) Italy.
Danilo LeonettiSection of Orthopaedics and Traumatology, Department of Biomedical Sciences and Morphological and Functional Images, University of Messina, 98122 Messina (ME) Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hip displacement and dislocation are among the most disabling musculoskeletal sequelae of cerebral palsy (CP) yet reported incidence and risk-factor estimates vary widely across studies. We undertook a systematic review and pooled analysis to quantify cumulative incidence across Gross Motor Function Classification System (GMFCS) strata and identify reproducible clinical and radiographic predictors. Methods: A protocol was registered in PROSPERO (CRD420251026860). MEDLINE (PubMed), Embase, CINAHL and CENTRAL were searched from inception to March 30, 2025. Eligible longitudinal studies enrolled ≥30 children with CP aged 2-18 years, provided ≥2 years' follow-up without confounding hip-directed intervention, and reported migration percentage (MP) data or equivalent permitting derivation. Hip displacement and dislocation were harmonized as MP >30 % and >50 %, respectively. Study quality was appraised with ROBINS I. Proportions were stabilized with the Freeman-Tukey double-arcsine transformation and pooled in random-effects (REML) models; odds ratios (ORs) for candidate predictors were combined using inverse-variance random-effects methods. Heterogeneity (I Results: Nineteen studies met inclusion; nine natural-history cohorts (n = 1556; median follow-up 5.1 y) contributed extractable incidence data. The pooled cumulative incidence of hip displacement/dislocation was 38.2 % (95 % CI 31.7-45.1 %; I Conclusions: Approximately four in ten children with CP, and more than two thirds of those in GMFCS IV-V, develop clinically important hip displacement without targeted intervention. GMFCS IV-V status and an early MP ≥ 30 % are robust, actionable triggers for intensifying hip surveillance to six-monthly radiography; pelvic obliquity ≥10° may further stratify risk but requires confirmation. Uniform MP thresholds, time-to-event analyses and reporting of modifiable exposures are needed in future multicenter cohorts to refine preventive care.

Indexed as

Cerebral palsyGMFCSHip dislocationIncidenceRisk factors

Identifiers

PMID40814403
PMCPMC12345335

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.